File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC

TitleDopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC
Authors
KeywordsTranscranial direct current stimulation
tDCS
Dopamine depletion
Flexibility
Learning
Issue Date2020
PublisherElsevier Inc. The Journal's web site is located at http://brainstimjrnl.com
Citation
Brain Stimulation, 2020, v. 13 n. 1, p. 105-108 How to Cite?
AbstractBackground: Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning. Method: A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility. Results: Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition. Conclusions: Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.
Persistent Identifierhttp://hdl.handle.net/10722/276068
ISSN
2023 Impact Factor: 7.6
2023 SCImago Journal Rankings: 2.438
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBorwick, C-
dc.contributor.authorLal, R-
dc.contributor.authorLim, LW-
dc.contributor.authorStagg, CJ-
dc.contributor.authorAquili, L-
dc.date.accessioned2019-09-10T02:55:18Z-
dc.date.available2019-09-10T02:55:18Z-
dc.date.issued2020-
dc.identifier.citationBrain Stimulation, 2020, v. 13 n. 1, p. 105-108-
dc.identifier.issn1935-861X-
dc.identifier.urihttp://hdl.handle.net/10722/276068-
dc.description.abstractBackground: Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning. Method: A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility. Results: Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition. Conclusions: Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://brainstimjrnl.com-
dc.relation.ispartofBrain Stimulation-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectTranscranial direct current stimulation-
dc.subjecttDCS-
dc.subjectDopamine depletion-
dc.subjectFlexibility-
dc.subjectLearning-
dc.titleDopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.brs.2019.08.016-
dc.identifier.pmid31494070-
dc.identifier.scopuseid_2-s2.0-85071664506-
dc.identifier.hkuros304751-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spage105-
dc.identifier.epage108-
dc.identifier.isiWOS:000499654900012-
dc.publisher.placeUnited States-
dc.identifier.issnl1876-4754-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats