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Article: Middle east respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Africa and Middle East

TitleMiddle east respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Africa and Middle East
Authors
KeywordsContract number I-005-436
Department of Health and Human Services
Epidemiology
General Organization for Veterinary Services
Jeddah
Issue Date2019
PublisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses
Citation
Viruses, 2019, v. 11 n. 8, p. article no. 717 How to Cite?
AbstractDromedary camels are the natural reservoirs of the Middle East respiratory syndrome coronavirus (MERS-CoV). Camels are mostly bred in East African countries then exported into Africa and Middle East for consumption. To understand the distribution of MERS-CoV among camels in North Africa and the Middle East, we conducted surveillance in Egypt, Senegal, Tunisia, Uganda, Jordan, Saudi Arabia, and Iraq. We also performed longitudinal studies of three camel herds in Egypt and Jordan to elucidate MERS-CoV infection and transmission. Between 2016 and 2018, a total of 4027 nasal swabs and 3267 serum samples were collected from all countries. Real- time PCR revealed that MERS-CoV RNA was detected in nasal swab samples from Egypt, Senegal, Tunisia, and Saudi Arabia. Microneutralization assay showed that antibodies were detected in all countries. Positive PCR samples were partially sequenced, and a phylogenetic tree was built. The tree suggested that all sequences are of clade C and sequences from camels in Egypt formed a separate group from previously published sequences. Longitudinal studies showed high seroprevalence in adult camels. These results indicate the widespread distribution of the virus in camels. A systematic active surveillance and longitudinal studies for MERS-CoV are needed to understand the epidemiology of the disease and dynamics of viral infection.
Persistent Identifierhttp://hdl.handle.net/10722/276146
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.140
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKandeil, A-
dc.contributor.authorGomaa, M-
dc.contributor.authorNageh, S-
dc.contributor.authorShehata, MM-
dc.contributor.authorKayed, AE-
dc.contributor.authorSabir, JSM-
dc.contributor.authorAbiadh, A-
dc.contributor.authorJrijer, J-
dc.contributor.authorAmr, Z-
dc.contributor.authorSaid, MA-
dc.contributor.authorByarugaba, DK-
dc.contributor.authorWabwire-Mangen, F-
dc.contributor.authorTugume, T-
dc.contributor.authorMohamed, NS-
dc.contributor.authorAttar, R-
dc.contributor.authorHassan, SM-
dc.contributor.authorLinjawi, SA-
dc.contributor.authorMoatassim, Y-
dc.contributor.authorKutkat, O-
dc.contributor.authorMahmoud, S-
dc.contributor.authorBagato, O-
dc.contributor.authorShama, NMA-
dc.contributor.authorEl-Shesheny, R-
dc.contributor.authorMostafa, A-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorChu, KW-
dc.contributor.authorHassan, N-
dc.contributor.authorElsokary, B-
dc.contributor.authorSaad, A-
dc.contributor.authorSobhy, H-
dc.contributor.authorEl Masry, I-
dc.contributor.authorMcKenzie, ZPP-
dc.contributor.authorWebby, RJ-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorMakonnen, YJ-
dc.contributor.authorAli, MA-
dc.contributor.authorKayali, G-
dc.date.accessioned2019-09-10T02:56:54Z-
dc.date.available2019-09-10T02:56:54Z-
dc.date.issued2019-
dc.identifier.citationViruses, 2019, v. 11 n. 8, p. article no. 717-
dc.identifier.issn1999-4915-
dc.identifier.urihttp://hdl.handle.net/10722/276146-
dc.description.abstractDromedary camels are the natural reservoirs of the Middle East respiratory syndrome coronavirus (MERS-CoV). Camels are mostly bred in East African countries then exported into Africa and Middle East for consumption. To understand the distribution of MERS-CoV among camels in North Africa and the Middle East, we conducted surveillance in Egypt, Senegal, Tunisia, Uganda, Jordan, Saudi Arabia, and Iraq. We also performed longitudinal studies of three camel herds in Egypt and Jordan to elucidate MERS-CoV infection and transmission. Between 2016 and 2018, a total of 4027 nasal swabs and 3267 serum samples were collected from all countries. Real- time PCR revealed that MERS-CoV RNA was detected in nasal swab samples from Egypt, Senegal, Tunisia, and Saudi Arabia. Microneutralization assay showed that antibodies were detected in all countries. Positive PCR samples were partially sequenced, and a phylogenetic tree was built. The tree suggested that all sequences are of clade C and sequences from camels in Egypt formed a separate group from previously published sequences. Longitudinal studies showed high seroprevalence in adult camels. These results indicate the widespread distribution of the virus in camels. A systematic active surveillance and longitudinal studies for MERS-CoV are needed to understand the epidemiology of the disease and dynamics of viral infection.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses-
dc.relation.ispartofViruses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectContract number I-005-436-
dc.subjectDepartment of Health and Human Services-
dc.subjectEpidemiology-
dc.subjectGeneral Organization for Veterinary Services-
dc.subjectJeddah-
dc.titleMiddle east respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Africa and Middle East-
dc.typeArticle-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailChu, KW: dkwchu@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityChu, KW=rp02512-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/v11080717-
dc.identifier.pmid31387326-
dc.identifier.scopuseid_2-s2.0-85070457737-
dc.identifier.hkuros304294-
dc.identifier.volume11-
dc.identifier.issue8-
dc.identifier.spagearticle no. 717-
dc.identifier.epagearticle no. 717-
dc.identifier.isiWOS:000482993900072-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1999-4915-

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