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- Publisher Website: 10.1016/j.yfrne.2019.100764
- Scopus: eid_2-s2.0-85065925035
- PMID: 31102663
- WOS: WOS:000482544100004
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Article: The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease
Title | The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease |
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Authors | |
Keywords | Sleep Circadian rhythm Alzheimer’s disease Glymphatic Dural lymphatics Orexin Oxidative stress Melatonin Stress granules |
Issue Date | 2019 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yfrne |
Citation | Frontiers in Neuroendocrinology, 2019, v. 54, article no. 100764 How to Cite? |
Abstract | Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer’s disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer’s disease in humans. |
Persistent Identifier | http://hdl.handle.net/10722/276229 |
ISSN | 2023 Impact Factor: 6.5 2023 SCImago Journal Rankings: 2.078 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, H | - |
dc.contributor.author | Dunnett, S | - |
dc.contributor.author | Ho, YS | - |
dc.contributor.author | Chang, RCC | - |
dc.date.accessioned | 2019-09-10T02:58:37Z | - |
dc.date.available | 2019-09-10T02:58:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Frontiers in Neuroendocrinology, 2019, v. 54, article no. 100764 | - |
dc.identifier.issn | 0091-3022 | - |
dc.identifier.uri | http://hdl.handle.net/10722/276229 | - |
dc.description.abstract | Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer’s disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer’s disease in humans. | - |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yfrne | - |
dc.relation.ispartof | Frontiers in Neuroendocrinology | - |
dc.subject | Sleep | - |
dc.subject | Circadian rhythm | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Glymphatic | - |
dc.subject | Dural lymphatics | - |
dc.subject | Orexin | - |
dc.subject | Oxidative stress | - |
dc.subject | Melatonin | - |
dc.subject | Stress granules | - |
dc.title | The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease | - |
dc.type | Article | - |
dc.identifier.email | Ho, YS: janiceys@hku.hk | - |
dc.identifier.email | Chang, RCC: rccchang@hku.hk | - |
dc.identifier.authority | Chang, RCC=rp00470 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.yfrne.2019.100764 | - |
dc.identifier.pmid | 31102663 | - |
dc.identifier.scopus | eid_2-s2.0-85065925035 | - |
dc.identifier.hkuros | 303900 | - |
dc.identifier.volume | 54 | - |
dc.identifier.spage | article no. 100764 | - |
dc.identifier.epage | article no. 100764 | - |
dc.identifier.isi | WOS:000482544100004 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0091-3022 | - |