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Article: Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions

TitleTyrosine negatively affects flexible-like behaviour under cognitively demanding conditions
Authors
KeywordsCognitive flexibility
Dopamine
Tyrosine
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad
Citation
Journal of Affective Disorders, 2020, v. 260, p. 329-333 How to Cite?
AbstractBackground: The catecholaminergic precursor to dopamine, tyrosine, is an important modulator of cognitive performance. A number of studies have demonstrated that the beneficial effects of tyrosine on cognitive performance are most pronounced when individuals are exposed to stressful situations, such as hypothermia. However, little is known about whether manipulation of stress using non-aversive stimuli, such as cognitive demand, can also bring about similar improvements. Methods: We conducted a randomized, double-blind, placebo-controlled experiment to test the effects of tyrosine administration and cognitive load (low or high) on cognitive flexibility, a measure known to be influenced by catecholaminergic function. A total of 70 healthy volunteers completed a baseline cognitive flexibility test (Wisconsin Card Sorting Test: WCST). Participants were given a dose of either tyrosine (2.0 g) or placebo (cellulose) and subject to either low cognitive load (simple reaction time task) or high cognitive load (digit memory span task), immediately followed by a WCST for a second time. Results: Contrary to expectations, we found that instead of ameliorating performance under the high cognitive load condition, tyrosine worsened cognitive flexibility. Limitations: Physiological marker of stress was not measured. Conclusions: Our results suggest that aversive stressors and cognitive demand modulate the effects of tyrosine on cognitive performance in a differential manner. © 2019
Persistent Identifierhttp://hdl.handle.net/10722/276242
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRobson, A-
dc.contributor.authorLim, LW-
dc.contributor.authorAquili, L-
dc.date.accessioned2019-09-10T02:58:53Z-
dc.date.available2019-09-10T02:58:53Z-
dc.date.issued2020-
dc.identifier.citationJournal of Affective Disorders, 2020, v. 260, p. 329-333-
dc.identifier.issn0165-0327-
dc.identifier.urihttp://hdl.handle.net/10722/276242-
dc.description.abstractBackground: The catecholaminergic precursor to dopamine, tyrosine, is an important modulator of cognitive performance. A number of studies have demonstrated that the beneficial effects of tyrosine on cognitive performance are most pronounced when individuals are exposed to stressful situations, such as hypothermia. However, little is known about whether manipulation of stress using non-aversive stimuli, such as cognitive demand, can also bring about similar improvements. Methods: We conducted a randomized, double-blind, placebo-controlled experiment to test the effects of tyrosine administration and cognitive load (low or high) on cognitive flexibility, a measure known to be influenced by catecholaminergic function. A total of 70 healthy volunteers completed a baseline cognitive flexibility test (Wisconsin Card Sorting Test: WCST). Participants were given a dose of either tyrosine (2.0 g) or placebo (cellulose) and subject to either low cognitive load (simple reaction time task) or high cognitive load (digit memory span task), immediately followed by a WCST for a second time. Results: Contrary to expectations, we found that instead of ameliorating performance under the high cognitive load condition, tyrosine worsened cognitive flexibility. Limitations: Physiological marker of stress was not measured. Conclusions: Our results suggest that aversive stressors and cognitive demand modulate the effects of tyrosine on cognitive performance in a differential manner. © 2019-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad-
dc.relation.ispartofJournal of Affective Disorders-
dc.subjectCognitive flexibility-
dc.subjectDopamine-
dc.subjectTyrosine-
dc.titleTyrosine negatively affects flexible-like behaviour under cognitively demanding conditions-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jad.2019.09.031-
dc.identifier.scopuseid_2-s2.0-85072048083-
dc.identifier.hkuros305018-
dc.identifier.volume260-
dc.identifier.spage329-
dc.identifier.epage333-
dc.identifier.isiWOS:000490428300044-
dc.publisher.placeNetherlands-
dc.identifier.issnl0165-0327-

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