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- Publisher Website: 10.1002/anie.201510638
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Article: Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Title | Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis |
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Authors | |
Keywords | synthetic methods arylation homogeneous catalysis ketones palladium |
Issue Date | 2016 |
Citation | Angewandte Chemie - International Edition, 2016, v. 55, n. 7, p. 2559-2563 How to Cite? |
Abstract | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated. Be direct: A direct α-C-H arylation of normal cyclopentanones with aryl bromides, enabled by palladium/amine cooperative catalysis, features an exceptionally high selectivity for monoarylation, use of readily available starting materials, good scalability, and broad functional-group tolerance. |
Persistent Identifier | http://hdl.handle.net/10722/276501 |
ISSN | 2023 Impact Factor: 16.1 2023 SCImago Journal Rankings: 5.300 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, Yan | - |
dc.contributor.author | Su, Tianshun | - |
dc.contributor.author | Huang, Zhongxing | - |
dc.contributor.author | Dong, Guangbin | - |
dc.date.accessioned | 2019-09-18T08:33:48Z | - |
dc.date.available | 2019-09-18T08:33:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Angewandte Chemie - International Edition, 2016, v. 55, n. 7, p. 2559-2563 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/276501 | - |
dc.description.abstract | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated. Be direct: A direct α-C-H arylation of normal cyclopentanones with aryl bromides, enabled by palladium/amine cooperative catalysis, features an exceptionally high selectivity for monoarylation, use of readily available starting materials, good scalability, and broad functional-group tolerance. | - |
dc.language | eng | - |
dc.relation.ispartof | Angewandte Chemie - International Edition | - |
dc.subject | synthetic methods | - |
dc.subject | arylation | - |
dc.subject | homogeneous catalysis | - |
dc.subject | ketones | - |
dc.subject | palladium | - |
dc.title | Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/anie.201510638 | - |
dc.identifier.scopus | eid_2-s2.0-84954413534 | - |
dc.identifier.volume | 55 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 2559 | - |
dc.identifier.epage | 2563 | - |
dc.identifier.eissn | 1521-3773 | - |
dc.identifier.isi | WOS:000369970500049 | - |
dc.identifier.issnl | 1433-7851 | - |