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- Publisher Website: 10.1039/c7cs00647k
- Scopus: eid_2-s2.0-85032633739
- PMID: 29034942
- WOS: WOS:000413933800004
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Article: Guanidinium-based "molecular glues" for modulation of biomolecular functions
| Title | Guanidinium-based "molecular glues" for modulation of biomolecular functions |
|---|---|
| Authors | |
| Issue Date | 2017 |
| Citation | Chemical Society Reviews, 2017, v. 46, n. 21, p. 6480-6491 How to Cite? |
| Abstract | © 2017 The Royal Society of Chemistry. Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions. |
| Persistent Identifier | http://hdl.handle.net/10722/276557 |
| ISSN | 2021 Impact Factor: 60.615 2020 SCImago Journal Rankings: 15.598 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mogaki, Rina | - |
| dc.contributor.author | Hashim, P. K. | - |
| dc.contributor.author | Okuro, Kou | - |
| dc.contributor.author | Aida, Takuzo | - |
| dc.date.accessioned | 2019-09-18T08:33:58Z | - |
| dc.date.available | 2019-09-18T08:33:58Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.citation | Chemical Society Reviews, 2017, v. 46, n. 21, p. 6480-6491 | - |
| dc.identifier.issn | 0306-0012 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/276557 | - |
| dc.description.abstract | © 2017 The Royal Society of Chemistry. Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Chemical Society Reviews | - |
| dc.title | Guanidinium-based "molecular glues" for modulation of biomolecular functions | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1039/c7cs00647k | - |
| dc.identifier.pmid | 29034942 | - |
| dc.identifier.scopus | eid_2-s2.0-85032633739 | - |
| dc.identifier.volume | 46 | - |
| dc.identifier.issue | 21 | - |
| dc.identifier.spage | 6480 | - |
| dc.identifier.epage | 6491 | - |
| dc.identifier.eissn | 1460-4744 | - |
| dc.identifier.isi | WOS:000413933800004 | - |
| dc.identifier.issnl | 0306-0012 | - |