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- Publisher Website: 10.1021/jacs.8b01094
- Scopus: eid_2-s2.0-85046019690
- PMID: 29629766
- WOS: WOS:000431095100001
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Article: Enantioselective γ-C(sp3)-H activation of alkyl amines via Pd(II)/Pd(0) catalysis
| Title | Enantioselective γ-C(sp3)-H activation of alkyl amines via Pd(II)/Pd(0) catalysis |
|---|---|
| Authors | |
| Issue Date | 2018 |
| Citation | Journal of the American Chemical Society, 2018, v. 140, n. 16, p. 5322-5325 How to Cite? |
| Abstract | © 2018 American Chemical Society. Pd(II)-catalyzed enantioselective γ-C(sp3)-H cross-coupling of alkyl amines via desymmetrization and kinetic resolution has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands (APAO). A diverse range of aryl- and vinyl-boron reagents can be used as coupling partners. The chiral γ-arylated alkylamine products are further transformed into chiral 2-substituted 1,2,3,4-tetra-hydroquinolines and spiro-pyrrolidines as important structural motifs in natural products and biologically active molecules. |
| Persistent Identifier | http://hdl.handle.net/10722/276587 |
| ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Shao, Qian | - |
| dc.contributor.author | Wu, Qing Feng | - |
| dc.contributor.author | He, Jian | - |
| dc.contributor.author | Yu, Jin Quan | - |
| dc.date.accessioned | 2019-09-18T08:34:03Z | - |
| dc.date.available | 2019-09-18T08:34:03Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | Journal of the American Chemical Society, 2018, v. 140, n. 16, p. 5322-5325 | - |
| dc.identifier.issn | 0002-7863 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/276587 | - |
| dc.description.abstract | © 2018 American Chemical Society. Pd(II)-catalyzed enantioselective γ-C(sp3)-H cross-coupling of alkyl amines via desymmetrization and kinetic resolution has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands (APAO). A diverse range of aryl- and vinyl-boron reagents can be used as coupling partners. The chiral γ-arylated alkylamine products are further transformed into chiral 2-substituted 1,2,3,4-tetra-hydroquinolines and spiro-pyrrolidines as important structural motifs in natural products and biologically active molecules. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Journal of the American Chemical Society | - |
| dc.title | Enantioselective γ-C(sp3)-H activation of alkyl amines via Pd(II)/Pd(0) catalysis | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1021/jacs.8b01094 | - |
| dc.identifier.pmid | 29629766 | - |
| dc.identifier.scopus | eid_2-s2.0-85046019690 | - |
| dc.identifier.volume | 140 | - |
| dc.identifier.issue | 16 | - |
| dc.identifier.spage | 5322 | - |
| dc.identifier.epage | 5325 | - |
| dc.identifier.eissn | 1520-5126 | - |
| dc.identifier.isi | WOS:000431095100001 | - |
| dc.identifier.issnl | 0002-7863 | - |