File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Relating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: an in vivo study

TitleRelating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: an in vivo study
Authors
KeywordsAtomic force microscopy
Cells
Cytology
Elastic moduli
Issue Date2019
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all
Citation
Biomaterials Science, 2019, v. 7 n. 6, p. 2545-2551 How to Cite?
AbstractThe blood thinning properties of pentoxifylline have been attributed to its ability to increase the deformability of red blood cells and improve their rheological properties. To interpret and substantiate these observations a novel approach is taken by measuring the stiffness of individual red blood cells from healthy humans before and after subscription to pentoxifylline for nine days. Atomic force microscopy nanoindentation experiments reveal that the elastic modulus of the red blood cells decreased by 30%–40%, after pentoxifylline subscription. This decrease in elastic modulus is related to the ability of pentoxifylline to increase the production of ATP and lower Ca2+ concentrations in red blood cells. The present in vivo experiments provide a deeper understanding of the mode of action of pentoxifylline, and pave the way to using indentation in medicine. A further unique advantage of this study is that it was performed on healthy volunteers, rather than requiring in vitro incubation.
Persistent Identifierhttp://hdl.handle.net/10722/277104
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 1.206
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAifantis, KE-
dc.contributor.authorShrivastava, S-
dc.contributor.authorPelidou, SH-
dc.contributor.authorNgan, AHW-
dc.contributor.authorBaloyannis, SI-
dc.date.accessioned2019-09-20T08:44:30Z-
dc.date.available2019-09-20T08:44:30Z-
dc.date.issued2019-
dc.identifier.citationBiomaterials Science, 2019, v. 7 n. 6, p. 2545-2551-
dc.identifier.issn2047-4830-
dc.identifier.urihttp://hdl.handle.net/10722/277104-
dc.description.abstractThe blood thinning properties of pentoxifylline have been attributed to its ability to increase the deformability of red blood cells and improve their rheological properties. To interpret and substantiate these observations a novel approach is taken by measuring the stiffness of individual red blood cells from healthy humans before and after subscription to pentoxifylline for nine days. Atomic force microscopy nanoindentation experiments reveal that the elastic modulus of the red blood cells decreased by 30%–40%, after pentoxifylline subscription. This decrease in elastic modulus is related to the ability of pentoxifylline to increase the production of ATP and lower Ca2+ concentrations in red blood cells. The present in vivo experiments provide a deeper understanding of the mode of action of pentoxifylline, and pave the way to using indentation in medicine. A further unique advantage of this study is that it was performed on healthy volunteers, rather than requiring in vitro incubation.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all-
dc.relation.ispartofBiomaterials Science-
dc.subjectAtomic force microscopy-
dc.subjectCells-
dc.subjectCytology-
dc.subjectElastic moduli-
dc.titleRelating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: an in vivo study-
dc.typeArticle-
dc.identifier.emailNgan, AHW: hwngan@hku.hk-
dc.identifier.authorityNgan, AHW=rp00225-
dc.description.naturepostprint-
dc.identifier.doi10.1039/C8BM01691G-
dc.identifier.pmid30973560-
dc.identifier.scopuseid_2-s2.0-85066634278-
dc.identifier.hkuros305440-
dc.identifier.volume7-
dc.identifier.issue6-
dc.identifier.spage2545-
dc.identifier.epage2551-
dc.identifier.isiWOS:000474065900025-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2047-4830-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats