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Article: More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration

TitleMore than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration
Authors
Keywordsartemisinin
inflammation
neuroinflammation
neurodegeneration
Alzheimer’s disease
Issue Date2019
PublisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/
Citation
Neural Regeneration Research, 2019, v. 14 n. 9, p. 1494-1498 How to Cite?
AbstractArtemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial agents, with few adverse side effects. Interestingly, evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria, including cancers, inflammatory diseases, and autoimmune disorders. Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions, whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders, including Alzheimer’s disease. Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation, inflammation, and amyloid beta protein (Aβ). In this review, we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities, suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.
Persistent Identifierhttp://hdl.handle.net/10722/277337
ISSN
2023 Impact Factor: 5.9
2023 SCImago Journal Rankings: 0.967
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLu, BW-
dc.contributor.authorBaum, L-
dc.contributor.authorSo, KF-
dc.contributor.authorChiu, K-
dc.contributor.authorXie, LK-
dc.date.accessioned2019-09-20T08:49:03Z-
dc.date.available2019-09-20T08:49:03Z-
dc.date.issued2019-
dc.identifier.citationNeural Regeneration Research, 2019, v. 14 n. 9, p. 1494-1498-
dc.identifier.issn1673-5374-
dc.identifier.urihttp://hdl.handle.net/10722/277337-
dc.description.abstractArtemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial agents, with few adverse side effects. Interestingly, evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria, including cancers, inflammatory diseases, and autoimmune disorders. Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions, whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders, including Alzheimer’s disease. Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation, inflammation, and amyloid beta protein (Aβ). In this review, we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities, suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.-
dc.languageeng-
dc.publisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/-
dc.relation.ispartofNeural Regeneration Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectartemisinin-
dc.subjectinflammation-
dc.subjectneuroinflammation-
dc.subjectneurodegeneration-
dc.subjectAlzheimer’s disease-
dc.titleMore than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration-
dc.typeArticle-
dc.identifier.emailLu, BW: willalu@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.emailChiu, K: datwai@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.authorityChiu, K=rp01973-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4103/1673-5374.255960-
dc.identifier.pmid31089038-
dc.identifier.pmcidPMC6557089-
dc.identifier.scopuseid_2-s2.0-85065829543-
dc.identifier.hkuros305549-
dc.identifier.volume14-
dc.identifier.issue9-
dc.identifier.spage1494-
dc.identifier.epage1498-
dc.identifier.isiWOS:000468060200004-
dc.publisher.placeChina-
dc.identifier.issnl1673-5374-

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