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- Publisher Website: 10.1073/pnas.0404195101
- Scopus: eid_2-s2.0-3242690413
- PMID: 15249670
- WOS: WOS:000222842700017
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Article: Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation
Title | Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation |
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Authors | |
Issue Date | 2004 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2004, v. 101, n. 29, p. 10572-10577 How to Cite? |
Abstract | Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosis-specific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the same genetic pathway for the establishment of close juxtaposition between homologous meiotic chromosomes. Biochemical studies indicate that Hop2 and Mnd1 proteins form a stable heterodimer with a higher affinity for double-stranded than single-stranded DNA, and that this heterodimer stimulates the strand assimilation activity of Dmc1 in vitro. Together, the genetic and biochemical results suggest that Hop2, Mnd1, and Dmc1 are functionally interdependent during meiotic DNA recombination. |
Persistent Identifier | http://hdl.handle.net/10722/277710 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, Yi Kai | - |
dc.contributor.author | Leng, Chih Hsiang | - |
dc.contributor.author | Olivares, Heidi | - |
dc.contributor.author | Lee, Ming Hui | - |
dc.contributor.author | Chang, Yuan Chih | - |
dc.contributor.author | Kung, Wen Mei | - |
dc.contributor.author | Ti, Shih Chieh | - |
dc.contributor.author | Lo, Yu Hui | - |
dc.contributor.author | Wang, Andrew H.J. | - |
dc.contributor.author | Chang, Chia Seng | - |
dc.contributor.author | Bishop, Douglas K. | - |
dc.contributor.author | Hsueh, Yi Ping | - |
dc.contributor.author | Wang, Ting Fang | - |
dc.date.accessioned | 2019-09-27T08:29:46Z | - |
dc.date.available | 2019-09-27T08:29:46Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2004, v. 101, n. 29, p. 10572-10577 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/277710 | - |
dc.description.abstract | Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosis-specific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the same genetic pathway for the establishment of close juxtaposition between homologous meiotic chromosomes. Biochemical studies indicate that Hop2 and Mnd1 proteins form a stable heterodimer with a higher affinity for double-stranded than single-stranded DNA, and that this heterodimer stimulates the strand assimilation activity of Dmc1 in vitro. Together, the genetic and biochemical results suggest that Hop2, Mnd1, and Dmc1 are functionally interdependent during meiotic DNA recombination. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.0404195101 | - |
dc.identifier.pmid | 15249670 | - |
dc.identifier.scopus | eid_2-s2.0-3242690413 | - |
dc.identifier.volume | 101 | - |
dc.identifier.issue | 29 | - |
dc.identifier.spage | 10572 | - |
dc.identifier.epage | 10577 | - |
dc.identifier.isi | WOS:000222842700017 | - |
dc.identifier.issnl | 0027-8424 | - |