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- Publisher Website: 10.1101/gad.1430406
- Scopus: eid_2-s2.0-33746604882
- PMID: 16847351
- WOS: WOS:000239504500012
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Article: SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae
Title | SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae |
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Authors | |
Keywords | Synaptomenal complex SUMO Meiosis Zip3 Zip1 Ulp2 |
Issue Date | 2006 |
Citation | Genes and Development, 2006, v. 20, n. 15, p. 2067-2081 How to Cite? |
Abstract | The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates synapsis between homologous chromosomes during meiotic prophase. In Saccharomyces cerevisiae, the Zip1 protein is the integral component of the SC. In the absence of a DNA double-strand break or the SC initiation protein Zip3, Zip1 proteins aggregate to form a polycomplex (PC). In addition, Zip1 is also responsible for DSB-independent nonhomologous centromere coupling at early meiotic prophase. We report here that Zip3 is a SUMO (small ubiquitin-related modifier) E3 ligase and that Zip1 is a binding protein for SUMO-conjugated products. Our results also suggest that at early meiotic prophase, Zip1 interacts with Zip3-independent Smt3 conjugates (e.g., Top2) to promote nonhomologous centromere coupling. At and after mid-prophase, the Zip1 protein begins to associate with Zip3-dependent Smt3 conjugates (e.g., Red1) along meiotic chromosomes in the wild-type cell to form SCs and with Smt3 polymeric chains in the zip3 mutant to form PCs. © 2006 by Cold Spring Harbor Laboratory Press. |
Persistent Identifier | http://hdl.handle.net/10722/277711 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 5.015 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheng, Chung Hsu | - |
dc.contributor.author | Lo, Yu Hui | - |
dc.contributor.author | Liang, Shu Shan | - |
dc.contributor.author | Ti, Shih Chieh | - |
dc.contributor.author | Lin, Feng Ming | - |
dc.contributor.author | Yeh, Chia Hui | - |
dc.contributor.author | Huang, Han Yi | - |
dc.contributor.author | Wang, Ting Fang | - |
dc.date.accessioned | 2019-09-27T08:29:46Z | - |
dc.date.available | 2019-09-27T08:29:46Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Genes and Development, 2006, v. 20, n. 15, p. 2067-2081 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10722/277711 | - |
dc.description.abstract | The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates synapsis between homologous chromosomes during meiotic prophase. In Saccharomyces cerevisiae, the Zip1 protein is the integral component of the SC. In the absence of a DNA double-strand break or the SC initiation protein Zip3, Zip1 proteins aggregate to form a polycomplex (PC). In addition, Zip1 is also responsible for DSB-independent nonhomologous centromere coupling at early meiotic prophase. We report here that Zip3 is a SUMO (small ubiquitin-related modifier) E3 ligase and that Zip1 is a binding protein for SUMO-conjugated products. Our results also suggest that at early meiotic prophase, Zip1 interacts with Zip3-independent Smt3 conjugates (e.g., Top2) to promote nonhomologous centromere coupling. At and after mid-prophase, the Zip1 protein begins to associate with Zip3-dependent Smt3 conjugates (e.g., Red1) along meiotic chromosomes in the wild-type cell to form SCs and with Smt3 polymeric chains in the zip3 mutant to form PCs. © 2006 by Cold Spring Harbor Laboratory Press. | - |
dc.language | eng | - |
dc.relation.ispartof | Genes and Development | - |
dc.subject | Synaptomenal complex | - |
dc.subject | SUMO | - |
dc.subject | Meiosis | - |
dc.subject | Zip3 | - |
dc.subject | Zip1 | - |
dc.subject | Ulp2 | - |
dc.title | SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1101/gad.1430406 | - |
dc.identifier.pmid | 16847351 | - |
dc.identifier.pmid | 16847351 | - |
dc.identifier.scopus | eid_2-s2.0-33746604882 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 15 | - |
dc.identifier.spage | 2067 | - |
dc.identifier.epage | 2081 | - |
dc.identifier.eissn | 1549-5477 | - |
dc.identifier.isi | WOS:000239504500012 | - |
dc.identifier.f1000 | 1033646 | - |
dc.identifier.issnl | 0890-9369 | - |