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Article: The extended chondrocyte lineage: implications for skeletal homeostasis and disorders

TitleThe extended chondrocyte lineage: implications for skeletal homeostasis and disorders
Authors
Keywordsanimal cell
bone development
bone disease
bone remodeling
cell dedifferentiation
Issue Date2019
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/ceb
Citation
Current Opinion in Cell Biology, 2019, v. 61, p. 132-140 How to Cite?
AbstractEndochondral bone formation relies on a finely controlled sequence of chondrocyte proliferation, maturation and hypertrophy that establishes the growth plate which, combined with the deposition of bone upon the cartilage template, mediates longitudinal skeletal growth. Recent lineage studies support a chondrocyte—osteoblast differentiation continuum and the presence of skeletal stem cells within cartilage. The biological significance of the lineage extension and the mechanisms controlling the process are unclear. In this review, we describe recent work on the extended chondrocyte—osteoblast lineage and its contribution to the development, growth and repair of bone and to bone disorders that provides insight into the process and the molecular controls involved. The implications for skeletal homeostasis are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/278068
ISSN
2020 Impact Factor: 8.382
2015 SCImago Journal Rankings: 7.046
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, KY-
dc.contributor.authorCheah, KSE-
dc.date.accessioned2019-10-04T08:06:53Z-
dc.date.available2019-10-04T08:06:53Z-
dc.date.issued2019-
dc.identifier.citationCurrent Opinion in Cell Biology, 2019, v. 61, p. 132-140-
dc.identifier.issn0955-0674-
dc.identifier.urihttp://hdl.handle.net/10722/278068-
dc.description.abstractEndochondral bone formation relies on a finely controlled sequence of chondrocyte proliferation, maturation and hypertrophy that establishes the growth plate which, combined with the deposition of bone upon the cartilage template, mediates longitudinal skeletal growth. Recent lineage studies support a chondrocyte—osteoblast differentiation continuum and the presence of skeletal stem cells within cartilage. The biological significance of the lineage extension and the mechanisms controlling the process are unclear. In this review, we describe recent work on the extended chondrocyte—osteoblast lineage and its contribution to the development, growth and repair of bone and to bone disorders that provides insight into the process and the molecular controls involved. The implications for skeletal homeostasis are discussed.-
dc.languageeng-
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/ceb-
dc.relation.ispartofCurrent Opinion in Cell Biology-
dc.subjectanimal cell-
dc.subjectbone development-
dc.subjectbone disease-
dc.subjectbone remodeling-
dc.subjectcell dedifferentiation-
dc.titleThe extended chondrocyte lineage: implications for skeletal homeostasis and disorders-
dc.typeArticle-
dc.identifier.emailTsang, KY: kytsang@HKUCC-COM.hku.hk-
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.authorityCheah, KSE=rp00342-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ceb.2019.07.011-
dc.identifier.pmid31541943-
dc.identifier.scopuseid_2-s2.0-85072241921-
dc.identifier.hkuros306359-
dc.identifier.volume61-
dc.identifier.spage132-
dc.identifier.epage140-
dc.identifier.isiWOS:000501828200019-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0955-0674-

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