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Article: Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: a systematic review and meta-analysis
Title | Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: a systematic review and meta-analysis |
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Authors | |
Keywords | dual antiplatelet therapy minor oral surgery bleeding haemostatic measures |
Issue Date | 2020 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijom |
Citation | International Journal of Oral and Maxillofacial Surgery, 2020, v. 49 n. 1, p. 90-98 How to Cite? |
Abstract | Bleeding is a feared complication of minor oral surgery in patients on treatment with antiplatelet agents and there is no agreed strategy regarding the cessation or not of antiplatelet treatment. The aim of this systematic review was to evaluate bleeding with minor oral surgery in patients on dual antiplatelet therapy (DAPT), single antiplatelet therapy (SAPT), or no antiplatelet therapy (no APT). The PubMed, Embase, Web of Science, and Cochrane Library databases were screened. Sixteen studies were included. DAPT was continued in all studies. The perioperative bleeding risk was significantly higher for DAPT than for SAPT (risk ratio (RR) 10.16, P = 0.010; risk difference (RD) 0.35, P = 0.269), but not higher compared to no APT (RR 6.50, P = 0.057; RD 0.19, P = 0.060). The postoperative bleeding risk was significantly elevated for DAPT compared to SAPT (RR 2.61, P = 0.010) and no APT (RR 3.63, P = 0.035), but only by 1% (RD 0.01, P = 0.103) and 1% (RD 0.01, P = 0.421), respectively. Clinically, this may be considered quite similar. Additionally, local haemostatic measures could control all reported bleeding and no lethal events occurred. Therefore, DAPT interruption is not advised before minor oral surgery. |
Persistent Identifier | http://hdl.handle.net/10722/278113 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.875 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ockerman, A | - |
dc.contributor.author | Bornstein, MM | - |
dc.contributor.author | Leung, YY | - |
dc.contributor.author | Li, SKY | - |
dc.contributor.author | Politis, C | - |
dc.contributor.author | Jacobs, R | - |
dc.date.accessioned | 2019-10-04T08:07:45Z | - |
dc.date.available | 2019-10-04T08:07:45Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Oral and Maxillofacial Surgery, 2020, v. 49 n. 1, p. 90-98 | - |
dc.identifier.issn | 0901-5027 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278113 | - |
dc.description.abstract | Bleeding is a feared complication of minor oral surgery in patients on treatment with antiplatelet agents and there is no agreed strategy regarding the cessation or not of antiplatelet treatment. The aim of this systematic review was to evaluate bleeding with minor oral surgery in patients on dual antiplatelet therapy (DAPT), single antiplatelet therapy (SAPT), or no antiplatelet therapy (no APT). The PubMed, Embase, Web of Science, and Cochrane Library databases were screened. Sixteen studies were included. DAPT was continued in all studies. The perioperative bleeding risk was significantly higher for DAPT than for SAPT (risk ratio (RR) 10.16, P = 0.010; risk difference (RD) 0.35, P = 0.269), but not higher compared to no APT (RR 6.50, P = 0.057; RD 0.19, P = 0.060). The postoperative bleeding risk was significantly elevated for DAPT compared to SAPT (RR 2.61, P = 0.010) and no APT (RR 3.63, P = 0.035), but only by 1% (RD 0.01, P = 0.103) and 1% (RD 0.01, P = 0.421), respectively. Clinically, this may be considered quite similar. Additionally, local haemostatic measures could control all reported bleeding and no lethal events occurred. Therefore, DAPT interruption is not advised before minor oral surgery. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijom | - |
dc.relation.ispartof | International Journal of Oral and Maxillofacial Surgery | - |
dc.subject | dual antiplatelet therapy | - |
dc.subject | minor oral surgery | - |
dc.subject | bleeding | - |
dc.subject | haemostatic measures | - |
dc.title | Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.identifier.email | Bornstein, MM: bornst@hku.hk | - |
dc.identifier.email | Leung, YY: mleung04@hku.hk | - |
dc.identifier.email | Li, SKY: skyli@hku.hk | - |
dc.identifier.authority | Bornstein, MM=rp02217 | - |
dc.identifier.authority | Leung, YY=rp01522 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ijom.2019.06.002 | - |
dc.identifier.scopus | eid_2-s2.0-85067550032 | - |
dc.identifier.hkuros | 307009 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 90 | - |
dc.identifier.epage | 98 | - |
dc.identifier.isi | WOS:000509624300013 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0901-5027 | - |