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- Publisher Website: 10.1039/C8BM00499D
- Scopus: eid_2-s2.0-85050772037
- PMID: 29882566
- WOS: WOS:000447712500009
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Article: Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel
Title | Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel |
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Authors | |
Keywords | Acrylic monomers Amides Biomaterials Cell culture Copper |
Issue Date | 2018 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all |
Citation | Biomaterials Science, 2018, v. 6 n. 8, p. 2110-2121 How to Cite? |
Abstract | Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration. |
Persistent Identifier | http://hdl.handle.net/10722/278226 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 1.206 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, M | - |
dc.contributor.author | LIU, X | - |
dc.contributor.author | TAN, L | - |
dc.contributor.author | CUI, Z | - |
dc.contributor.author | YANG, X | - |
dc.contributor.author | LI, Z | - |
dc.contributor.author | ZHENG, Y | - |
dc.contributor.author | Yeung, KWK | - |
dc.contributor.author | CHU, PK | - |
dc.contributor.author | WU, S | - |
dc.date.accessioned | 2019-10-04T08:09:55Z | - |
dc.date.available | 2019-10-04T08:09:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Biomaterials Science, 2018, v. 6 n. 8, p. 2110-2121 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278226 | - |
dc.description.abstract | Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all | - |
dc.relation.ispartof | Biomaterials Science | - |
dc.subject | Acrylic monomers | - |
dc.subject | Amides | - |
dc.subject | Biomaterials | - |
dc.subject | Cell culture | - |
dc.subject | Copper | - |
dc.title | Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel | - |
dc.type | Article | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/C8BM00499D | - |
dc.identifier.pmid | 29882566 | - |
dc.identifier.scopus | eid_2-s2.0-85050772037 | - |
dc.identifier.hkuros | 306870 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 2110 | - |
dc.identifier.epage | 2121 | - |
dc.identifier.isi | WOS:000447712500009 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2047-4830 | - |