File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel

TitleNoninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel
Authors
KeywordsAcrylic monomers
Amides
Biomaterials
Cell culture
Copper
Issue Date2018
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all
Citation
Biomaterials Science, 2018, v. 6 n. 8, p. 2110-2121 How to Cite?
AbstractBacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/278226
ISSN
2020 Impact Factor: 6.843
2015 SCImago Journal Rankings: 1.347
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLI, M-
dc.contributor.authorLIU, X-
dc.contributor.authorTAN, L-
dc.contributor.authorCUI, Z-
dc.contributor.authorYANG, X-
dc.contributor.authorLI, Z-
dc.contributor.authorZHENG, Y-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCHU, PK-
dc.contributor.authorWU, S-
dc.date.accessioned2019-10-04T08:09:55Z-
dc.date.available2019-10-04T08:09:55Z-
dc.date.issued2018-
dc.identifier.citationBiomaterials Science, 2018, v. 6 n. 8, p. 2110-2121-
dc.identifier.issn2047-4830-
dc.identifier.urihttp://hdl.handle.net/10722/278226-
dc.description.abstractBacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all-
dc.relation.ispartofBiomaterials Science-
dc.subjectAcrylic monomers-
dc.subjectAmides-
dc.subjectBiomaterials-
dc.subjectCell culture-
dc.subjectCopper-
dc.titleNoninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C8BM00499D-
dc.identifier.pmid29882566-
dc.identifier.scopuseid_2-s2.0-85050772037-
dc.identifier.hkuros306870-
dc.identifier.volume6-
dc.identifier.issue8-
dc.identifier.spage2110-
dc.identifier.epage2121-
dc.identifier.isiWOS:000447712500009-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2047-4830-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats