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- Publisher Website: 10.1038/s41419-018-1198-1
- Scopus: eid_2-s2.0-85065556111
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Article: Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa
Title | Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa |
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Authors | |
Keywords | animal cell animal experiment animal model animal tissue apoptosis |
Issue Date | 2018 |
Publisher | Nature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/cddis/index.html |
Citation | Cell Death & Disease, 2018, v. 9 n. 12, p. article no. 1141 How to Cite? |
Abstract | Retinitis pigmentosa (RP) is a heterogeneous group of inherited disorders caused by mutations in genes that are mostly expressed by rod photoreceptors, which results in initial death of rods followed by cone photoreceptors. The molecular mechanisms that lead to both rod and cone degeneration are not yet fully understood. The mTOR pathway is implicated in RP. However, it remains unclear whether S6K1 plays an essential role downstream of the mTOR pathway in mediating photoreceptor survival in RP. Our in vitro studies demonstrated that PTEN (phosphatase and tensin homolog) overexpression deactivated mTOR activity and induced 661W cone cell apoptosis. In addition, we identified that S6K1 but not 4EBP1 was the downstream effector of PTEN neurotoxicity using gain- and loss-of-function approaches. Moreover, our in vivo data corroborated the results of our in vitro studies. S6K1 overexpression either in rods or cones promoted these cell survival and function and improved visual performance in the rd10 mouse model of RP. Our data demonstrated that S6K1 was the downstream effector of mTOR and that S6K1 was critical for both rod and cone survival in RP. Our findings make a strong case for targeting S6K1 as a promising therapeutic strategy for promoting the survival of photoreceptors in RP. |
Persistent Identifier | http://hdl.handle.net/10722/279033 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 2.447 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, B | - |
dc.contributor.author | Xiong, G | - |
dc.contributor.author | Yang, W | - |
dc.date.accessioned | 2019-10-21T02:18:24Z | - |
dc.date.available | 2019-10-21T02:18:24Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cell Death & Disease, 2018, v. 9 n. 12, p. article no. 1141 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279033 | - |
dc.description.abstract | Retinitis pigmentosa (RP) is a heterogeneous group of inherited disorders caused by mutations in genes that are mostly expressed by rod photoreceptors, which results in initial death of rods followed by cone photoreceptors. The molecular mechanisms that lead to both rod and cone degeneration are not yet fully understood. The mTOR pathway is implicated in RP. However, it remains unclear whether S6K1 plays an essential role downstream of the mTOR pathway in mediating photoreceptor survival in RP. Our in vitro studies demonstrated that PTEN (phosphatase and tensin homolog) overexpression deactivated mTOR activity and induced 661W cone cell apoptosis. In addition, we identified that S6K1 but not 4EBP1 was the downstream effector of PTEN neurotoxicity using gain- and loss-of-function approaches. Moreover, our in vivo data corroborated the results of our in vitro studies. S6K1 overexpression either in rods or cones promoted these cell survival and function and improved visual performance in the rd10 mouse model of RP. Our data demonstrated that S6K1 was the downstream effector of mTOR and that S6K1 was critical for both rod and cone survival in RP. Our findings make a strong case for targeting S6K1 as a promising therapeutic strategy for promoting the survival of photoreceptors in RP. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/cddis/index.html | - |
dc.relation.ispartof | Cell Death & Disease | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | apoptosis | - |
dc.title | Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa | - |
dc.type | Article | - |
dc.identifier.email | Xiong, G: gyxiong@hku.hk | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41419-018-1198-1 | - |
dc.identifier.pmid | 30442943 | - |
dc.identifier.pmcid | PMC6237824 | - |
dc.identifier.scopus | eid_2-s2.0-85065556111 | - |
dc.identifier.hkuros | 307402 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | article no. 1141 | - |
dc.identifier.epage | article no. 1141 | - |
dc.identifier.isi | WOS:000450152300004 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-4889 | - |