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Article: Dose volume effects of re‐irradiation for locally recurrent nasopharyngeal carcinoma

TitleDose volume effects of re‐irradiation for locally recurrent nasopharyngeal carcinoma
Authors
Ng, WTLee, MCHFung, NTCWong, ECYCheung, AKWChow, JCHAu, KHPoon, DMCLai, JWYChiang, CLChoi, HCWChau, TCLee, VHFLee, AWM
KeywordsLocal recurrence
Nasopharyngeal carcinoma
Re‐irradiation
Salvage
Toxicities
Issue Date2020
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347
Citation
Head & Neck, 2020, v. 42 n. 2, p. 180-187 How to Cite?
DOI: http://dx.doi.org/10.1002/hed.25988
AbstractBackground: This study analyzed the dose volume effects of re‐irradiation for locally recurrent nasopharyngeal carcinoma (NPC) and attempts to determine the optimal dose for the best survival. Methods: Ninety‐one patients were studied. The local control, fatal complication, and overall survival were analyzed against the dose (in Equivalent Dose at 2 Gy/fractions) and recurrent gross tumor volume (GTV). Results: The local control and fatal complication rate appear to increase with prescribed dose. The overall survival peaks at around 60 Gy10. Local control decreases significantly with increasing GTV (P < .001) while overall survival shows similar trend (P = .06). No correlation was observed between the fatal complication rate and GTV volume. The dose response of local control appears to be stronger for smaller tumors. Conclusion: GTV volume plays a significant role in local control. A 60 Gy10 appears to be optimal for the best survival outcome; higher doses might be considered for small tumors.
Persistent Identifierhttp://hdl.handle.net/10722/279390
ISSN
1043-3074
2021 Impact Factor: 3.821
2020 SCImago Journal Rankings: 1.012
ISI Accession Number ID
WOS:000491180200001

 

DC FieldValueLanguage
dc.contributor.authorNg, WT-
dc.contributor.authorLee, MCH-
dc.contributor.authorFung, NTC-
dc.contributor.authorWong, ECY-
dc.contributor.authorCheung, AKW-
dc.contributor.authorChow, JCH-
dc.contributor.authorAu, KH-
dc.contributor.authorPoon, DMC-
dc.contributor.authorLai, JWY-
dc.contributor.authorChiang, CL-
dc.contributor.authorChoi, HCW-
dc.contributor.authorChau, TC-
dc.contributor.authorLee, VHF-
dc.contributor.authorLee, AWM-
dc.date.accessioned2019-11-01T07:16:25Z-
dc.date.available2019-11-01T07:16:25Z-
dc.date.issued2020-
dc.identifier.citationHead & Neck, 2020, v. 42 n. 2, p. 180-187-
dc.identifier.issn1043-3074-
dc.identifier.urihttp://hdl.handle.net/10722/279390-
dc.description.abstractBackground: This study analyzed the dose volume effects of re‐irradiation for locally recurrent nasopharyngeal carcinoma (NPC) and attempts to determine the optimal dose for the best survival. Methods: Ninety‐one patients were studied. The local control, fatal complication, and overall survival were analyzed against the dose (in Equivalent Dose at 2 Gy/fractions) and recurrent gross tumor volume (GTV). Results: The local control and fatal complication rate appear to increase with prescribed dose. The overall survival peaks at around 60 Gy10. Local control decreases significantly with increasing GTV (P < .001) while overall survival shows similar trend (P = .06). No correlation was observed between the fatal complication rate and GTV volume. The dose response of local control appears to be stronger for smaller tumors. Conclusion: GTV volume plays a significant role in local control. A 60 Gy10 appears to be optimal for the best survival outcome; higher doses might be considered for small tumors.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347-
dc.relation.ispartofHead & Neck-
dc.subjectLocal recurrence-
dc.subjectNasopharyngeal carcinoma-
dc.subjectRe‐irradiation-
dc.subjectSalvage-
dc.subjectToxicities-
dc.titleDose volume effects of re‐irradiation for locally recurrent nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailNg, WT: ngwt1@hkucc.hku.hk-
dc.identifier.emailChiang, CL: chiangcl@hku.hk-
dc.identifier.emailChoi, HCW: hcchoi@hku.hk-
dc.identifier.emailChau, TC: chautc@HKUCC-COM.hku.hk-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.authorityNg, WT=rp02671-
dc.identifier.authorityChiang, CL=rp02241-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.authorityLee, AWM=rp02056-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.25988-
dc.identifier.pmid31617636-
dc.identifier.scopuseid_2-s2.0-85074081579-
dc.identifier.hkuros308487-
dc.identifier.volume42-
dc.identifier.issue2-
dc.identifier.spage180-
dc.identifier.epage187-
dc.identifier.isiWOS:000491180200001-
dc.publisher.placeUnited States-
dc.identifier.issnl1043-3074-

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