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Article: Non-parametric overdose control for dose finding in drug combination trials
Title | Non-parametric overdose control for dose finding in drug combination trials |
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Authors | |
Keywords | Bayesian model selection Drug combination Loss function Maximum tolerated dose contour Non‐parametric design |
Issue Date | 2019 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1467-9876 |
Citation | Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68 n. 4, p. 1111-1130 How to Cite? |
Abstract | With the emergence of novel targeted anticancer agents, drug combinations have been recognized as cutting edge development in oncology. However, limited attention has been paid to overdose control in the existing drug combination dose finding methods which simultaneously find a set of maximum tolerated dose (MTD) combinations. To enhance patient safety, we develop the multiple‐agent non‐parametric overdose control (MANOC) design for identifying the MTD combination in phase I drug combination trials. By minimizing an asymmetric loss function, we control the probability of overdosing in a local region of the current dose combination. We further extend the MANOC design to identify the MTD contour by conducting a sequence of single‐agent subtrials with the dose level of one agent fixed. Simulation studies are conducted to investigate the performance of the designs proposed. Although the MANOC design can prevent patients from being allocated to overtoxic dose levels, its accuracy and efficiency in dose finding remain competitive with existing methods. As an illustration, the MANOC design is applied to a phase I clinical trial for identifying the MTD combinations of buparlisib and trametinib. |
Persistent Identifier | http://hdl.handle.net/10722/279511 |
ISSN | 2023 Impact Factor: 1.0 2023 SCImago Journal Rankings: 0.739 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LAM, CK | - |
dc.contributor.author | LIN, R | - |
dc.contributor.author | Yin, G | - |
dc.date.accessioned | 2019-11-01T07:18:46Z | - |
dc.date.available | 2019-11-01T07:18:46Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68 n. 4, p. 1111-1130 | - |
dc.identifier.issn | 0035-9254 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279511 | - |
dc.description.abstract | With the emergence of novel targeted anticancer agents, drug combinations have been recognized as cutting edge development in oncology. However, limited attention has been paid to overdose control in the existing drug combination dose finding methods which simultaneously find a set of maximum tolerated dose (MTD) combinations. To enhance patient safety, we develop the multiple‐agent non‐parametric overdose control (MANOC) design for identifying the MTD combination in phase I drug combination trials. By minimizing an asymmetric loss function, we control the probability of overdosing in a local region of the current dose combination. We further extend the MANOC design to identify the MTD contour by conducting a sequence of single‐agent subtrials with the dose level of one agent fixed. Simulation studies are conducted to investigate the performance of the designs proposed. Although the MANOC design can prevent patients from being allocated to overtoxic dose levels, its accuracy and efficiency in dose finding remain competitive with existing methods. As an illustration, the MANOC design is applied to a phase I clinical trial for identifying the MTD combinations of buparlisib and trametinib. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1467-9876 | - |
dc.relation.ispartof | Journal of the Royal Statistical Society: Series C (Applied Statistics) | - |
dc.subject | Bayesian model selection | - |
dc.subject | Drug combination | - |
dc.subject | Loss function | - |
dc.subject | Maximum tolerated dose contour | - |
dc.subject | Non‐parametric design | - |
dc.title | Non-parametric overdose control for dose finding in drug combination trials | - |
dc.type | Article | - |
dc.identifier.email | Yin, G: gyin@hku.hk | - |
dc.identifier.authority | Yin, G=rp00831 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/rssc.12349 | - |
dc.identifier.scopus | eid_2-s2.0-85063664180 | - |
dc.identifier.hkuros | 308630 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1111 | - |
dc.identifier.epage | 1130 | - |
dc.identifier.isi | WOS:000475984600013 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0035-9254 | - |