File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: GermlncRNA: A unique catalogue of long non-coding RNAs and associated regulations in male germ cell development

TitleGermlncRNA: A unique catalogue of long non-coding RNAs and associated regulations in male germ cell development
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at https://academic.oup.com/database
Citation
Database: The Journal of Biological Databases and Curation, 2015, v. 2015, article no. bav044 How to Cite?
AbstractSpermatogenic failure is a major cause of male infertility, which affects millions of couples worldwide. Recent discovery of long non-coding RNAs (lncRNAs) as critical regulators in normal and disease development provides new clues for delineating the molecular regulation in male germ cell development. However, few functional lncRNAs have been characterized to date. A major limitation in studying lncRNA in male germ cell development is the absence of germ cell-specific lncRNA annotation. Current lncRNA annotations are assembled by transcriptome data from heterogeneous tissue sources; specific germ cell transcript information of various developmental stages is therefore under-represented, which may lead to biased prediction or fail to identity important germ cell-specific lncRNAs. GermlncRNA provides the first comprehensive web-based and open-access lncRNA catalogue for three key male germ cell stages, including type A spermatogonia, pachytene spermatocytes and round spermatids. This information has been developed by integrating male germ transcriptome resources derived from RNA-Seq, tiling microarray and GermSAGE. Characterizations on lncRNA-associated regulatory features, potential coding gene and microRNA targets are also provided. Search results from GermlncRNA can be exported to Galaxy for downstream analysis or downloaded locally. Taken together, GermlncRNA offers a new avenue to better understand the role of lncRNAs and associated targets during spermatogenesis. Database URL: http://germlncrna.cbiit.cuhk.edu.hk/
Persistent Identifierhttp://hdl.handle.net/10722/279890
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.556
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuk, ACS-
dc.contributor.authorGao, H-
dc.contributor.authorXiao, S-
dc.contributor.authorLiao, J-
dc.contributor.authorWang, D-
dc.contributor.authorTu, J-
dc.contributor.authorRennert, OM-
dc.contributor.authorChan, WY-
dc.contributor.authorLee, TL-
dc.date.accessioned2019-12-18T07:46:10Z-
dc.date.available2019-12-18T07:46:10Z-
dc.date.issued2015-
dc.identifier.citationDatabase: The Journal of Biological Databases and Curation, 2015, v. 2015, article no. bav044-
dc.identifier.issn1758-0463-
dc.identifier.urihttp://hdl.handle.net/10722/279890-
dc.description.abstractSpermatogenic failure is a major cause of male infertility, which affects millions of couples worldwide. Recent discovery of long non-coding RNAs (lncRNAs) as critical regulators in normal and disease development provides new clues for delineating the molecular regulation in male germ cell development. However, few functional lncRNAs have been characterized to date. A major limitation in studying lncRNA in male germ cell development is the absence of germ cell-specific lncRNA annotation. Current lncRNA annotations are assembled by transcriptome data from heterogeneous tissue sources; specific germ cell transcript information of various developmental stages is therefore under-represented, which may lead to biased prediction or fail to identity important germ cell-specific lncRNAs. GermlncRNA provides the first comprehensive web-based and open-access lncRNA catalogue for three key male germ cell stages, including type A spermatogonia, pachytene spermatocytes and round spermatids. This information has been developed by integrating male germ transcriptome resources derived from RNA-Seq, tiling microarray and GermSAGE. Characterizations on lncRNA-associated regulatory features, potential coding gene and microRNA targets are also provided. Search results from GermlncRNA can be exported to Galaxy for downstream analysis or downloaded locally. Taken together, GermlncRNA offers a new avenue to better understand the role of lncRNAs and associated targets during spermatogenesis. Database URL: http://germlncrna.cbiit.cuhk.edu.hk/-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at https://academic.oup.com/database-
dc.relation.ispartofDatabase: The Journal of Biological Databases and Curation-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleGermlncRNA: A unique catalogue of long non-coding RNAs and associated regulations in male germ cell development-
dc.typeArticle-
dc.identifier.emailXiao, S: szxiao@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/database/bav044-
dc.identifier.pmid25982314-
dc.identifier.pmid25982314-
dc.identifier.scopuseid_2-s2.0-84945182838-
dc.identifier.volume2015-
dc.identifier.spagearticle no. bav044-
dc.identifier.epagearticle no. bav044-
dc.identifier.isiWOS:000361051400001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1758-0463-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats