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- Publisher Website: 10.1093/bioinformatics/btz210
- Scopus: eid_2-s2.0-85071048049
- PMID: 30903160
- WOS: WOS:000499323200049
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Article: TISIDB: an integrated repository portal for tumor–immune system interactions
Title | TISIDB: an integrated repository portal for tumor–immune system interactions |
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Authors | |
Keywords | Genes Computational Biology Pathway enrichment |
Issue Date | 2019 |
Publisher | Oxford University Press (OUP): Policy B - Oxford Open Option B. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/ |
Citation | Bioinformatics, 2019, v. 35 n. 20, p. 4200-4202 How to Cite? |
Abstract | The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. |
Persistent Identifier | http://hdl.handle.net/10722/280113 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 2.574 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | RU, B | - |
dc.contributor.author | Wong, CN | - |
dc.contributor.author | Tong, Y | - |
dc.contributor.author | Zhong, JY | - |
dc.contributor.author | Zhong, SSW | - |
dc.contributor.author | Wu, WC | - |
dc.contributor.author | Chu, KC | - |
dc.contributor.author | Wong, CY | - |
dc.contributor.author | Lau, CY | - |
dc.contributor.author | Chen, I | - |
dc.contributor.author | Chan, NW | - |
dc.contributor.author | Zhang, J | - |
dc.date.accessioned | 2020-01-06T02:01:09Z | - |
dc.date.available | 2020-01-06T02:01:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Bioinformatics, 2019, v. 35 n. 20, p. 4200-4202 | - |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.uri | http://hdl.handle.net/10722/280113 | - |
dc.description.abstract | The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press (OUP): Policy B - Oxford Open Option B. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/ | - |
dc.relation.ispartof | Bioinformatics | - |
dc.subject | Genes | - |
dc.subject | Computational Biology | - |
dc.subject | Pathway enrichment | - |
dc.title | TISIDB: an integrated repository portal for tumor–immune system interactions | - |
dc.type | Article | - |
dc.identifier.email | Tong, Y: tongyin9@hku.hk | - |
dc.identifier.email | Zhang, J: jzhang1@hku.hk | - |
dc.identifier.authority | Zhang, J=rp01713 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/bioinformatics/btz210 | - |
dc.identifier.pmid | 30903160 | - |
dc.identifier.scopus | eid_2-s2.0-85071048049 | - |
dc.identifier.hkuros | 308894 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 4200 | - |
dc.identifier.epage | 4202 | - |
dc.identifier.isi | WOS:000499323200049 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1367-4803 | - |