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Article: A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders

TitleA comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders
Authors
KeywordsCognitive-behavioral therapy
Major depressive disorders
Outpatients
China
Issue Date2014
Citation
Journal of Affective Disorders, 2014, v. 152-154, n. 1, p. 262-267 How to Cite?
AbstractBackground No study has examined the effect of cognitive-behavioral therapy (CBT) on moderate-severe major depressive disorders (MDD) in China. The objective of this study was to evaluate the effect of CBT, antidepressants alone (MED), combined CBT and antidepressants (COMB) and standard treatment (ST; i.e.; receiving psycho-educational intervention and/or medication treatment determined by treating psychiatrists) on depressive symptoms and social functioning in Chinese patients with moderate-severe MDD. Method A total of 180 patients diagnosed with MDD according to ICD-10 were randomly allocated to one of the four treatment regimens for a period of 6 months. Depressive symptoms were measured using the Hamilton Rating Scale for Depression (HAMD) and the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR). Remission threshold was defined as a C-QIDS-SR total score of <5. Social functioning was evaluated with the Work and Social Adjustment Scale (WSAS). All outcome measures were evaluated at entry, and at 3- and 6-months follow-up. Results At the 6-months assessment, the remission rates in the whole sample (n=96), the MED, the CBT, the COMB and the ST groups were 54.2%, 48%, 75%, 53.5% and 50%, respectively. Following the treatment periods, there was no significant difference in any of the study outcomes between the four groups. However, the CBT showed the greatest effect in the HAMD total score with the effect size=0.94, whereas the ST has only a moderate effect size in the WSAS total score (effect size=0.47). Conclusions The findings support the feasibility and effectiveness of CBT as a psychosocial intervention for Chinese patients with moderate-severe MDD. We also found that single treatment using MED or CBT performed equally well as the combined CBT-antidepressant treatment in controlling the remission. The study provided important knowledge to inform the mental health care planning in China. © 2013 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/280802
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZu, Si-
dc.contributor.authorXiang, Yu Tao-
dc.contributor.authorLiu, Jing-
dc.contributor.authorZhang, Ling-
dc.contributor.authorWang, Gang-
dc.contributor.authorMa, Xin-
dc.contributor.authorKilbourne, Amy M.-
dc.contributor.authorUngvari, Gabor S.-
dc.contributor.authorChiu, Helen F.K.-
dc.contributor.authorLai, Kelly Y.C.-
dc.contributor.authorWong, Samuel Y.S.-
dc.contributor.authorYu, Doris S.F.-
dc.contributor.authorLi, Zhan Jiang-
dc.date.accessioned2020-02-17T14:34:59Z-
dc.date.available2020-02-17T14:34:59Z-
dc.date.issued2014-
dc.identifier.citationJournal of Affective Disorders, 2014, v. 152-154, n. 1, p. 262-267-
dc.identifier.issn0165-0327-
dc.identifier.urihttp://hdl.handle.net/10722/280802-
dc.description.abstractBackground No study has examined the effect of cognitive-behavioral therapy (CBT) on moderate-severe major depressive disorders (MDD) in China. The objective of this study was to evaluate the effect of CBT, antidepressants alone (MED), combined CBT and antidepressants (COMB) and standard treatment (ST; i.e.; receiving psycho-educational intervention and/or medication treatment determined by treating psychiatrists) on depressive symptoms and social functioning in Chinese patients with moderate-severe MDD. Method A total of 180 patients diagnosed with MDD according to ICD-10 were randomly allocated to one of the four treatment regimens for a period of 6 months. Depressive symptoms were measured using the Hamilton Rating Scale for Depression (HAMD) and the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR). Remission threshold was defined as a C-QIDS-SR total score of <5. Social functioning was evaluated with the Work and Social Adjustment Scale (WSAS). All outcome measures were evaluated at entry, and at 3- and 6-months follow-up. Results At the 6-months assessment, the remission rates in the whole sample (n=96), the MED, the CBT, the COMB and the ST groups were 54.2%, 48%, 75%, 53.5% and 50%, respectively. Following the treatment periods, there was no significant difference in any of the study outcomes between the four groups. However, the CBT showed the greatest effect in the HAMD total score with the effect size=0.94, whereas the ST has only a moderate effect size in the WSAS total score (effect size=0.47). Conclusions The findings support the feasibility and effectiveness of CBT as a psychosocial intervention for Chinese patients with moderate-severe MDD. We also found that single treatment using MED or CBT performed equally well as the combined CBT-antidepressant treatment in controlling the remission. The study provided important knowledge to inform the mental health care planning in China. © 2013 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofJournal of Affective Disorders-
dc.subjectCognitive-behavioral therapy-
dc.subjectMajor depressive disorders-
dc.subjectOutpatients-
dc.subjectChina-
dc.titleA comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jad.2013.09.022-
dc.identifier.pmid24140226-
dc.identifier.scopuseid_2-s2.0-84889080216-
dc.identifier.volume152-154-
dc.identifier.issue1-
dc.identifier.spage262-
dc.identifier.epage267-
dc.identifier.eissn1573-2517-
dc.identifier.isiWOS:000327763600035-
dc.identifier.issnl0165-0327-

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