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- Publisher Website: 10.1111/jop.13003
- Scopus: eid_2-s2.0-85080872992
- PMID: 32027406
- WOS: WOS:000561629400001
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Article: ‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection
Title | ‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection |
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Authors | |
Keywords | biomarkers oral squamous cell carcinoma saliva |
Issue Date | 2020 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714 |
Citation | Journal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719 How to Cite? |
Abstract | Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350,000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐ and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or ‘risk‐stratifying’ saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential. |
Persistent Identifier | http://hdl.handle.net/10722/280961 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.716 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ADEOYE, J | - |
dc.contributor.author | Brennan, PA | - |
dc.contributor.author | Thomson, PJ | - |
dc.date.accessioned | 2020-02-25T07:43:19Z | - |
dc.date.available | 2020-02-25T07:43:19Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Journal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | http://hdl.handle.net/10722/280961 | - |
dc.description.abstract | Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350,000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐ and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or ‘risk‐stratifying’ saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714 | - |
dc.relation.ispartof | Journal of Oral Pathology & Medicine | - |
dc.rights | Postprint This is the peer reviewed version of the following article: [Journal of Oral Pathology & Medicine, 2020, v. 49 n. 8, p. 711-719], which has been published in final form at [http://dx.doi.org/10.1111/jop.13003]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | biomarkers | - |
dc.subject | oral squamous cell carcinoma | - |
dc.subject | saliva | - |
dc.title | ‘Search less, verify more’ – Reviewing salivary biomarkers in oral cancer detection | - |
dc.type | Article | - |
dc.identifier.email | Thomson, PJ: thomsonp@hku.hk | - |
dc.identifier.authority | Thomson, PJ=rp02327 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/jop.13003 | - |
dc.identifier.pmid | 32027406 | - |
dc.identifier.scopus | eid_2-s2.0-85080872992 | - |
dc.identifier.hkuros | 309151 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 711 | - |
dc.identifier.epage | 719 | - |
dc.identifier.isi | WOS:000561629400001 | - |
dc.publisher.place | Denmark | - |
dc.identifier.issnl | 0904-2512 | - |