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- Publisher Website: 10.1016/j.lungcan.2020.01.004
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- PMID: 31926983
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Article: Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer
Title | Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer |
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Authors | |
Keywords | Lung cancer Neutropenia Predictive models |
Issue Date | 2020 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan |
Citation | Lung Cancer, 2020, v. 141, p. 14-20 How to Cite? |
Abstract | Objectives:
Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer.
Materials and Methods:
Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included. The data were split into training and testing sets. In order to enhance the prediction accuracy and the reliability of the prediction model, lasso method was used for both variable selection and regularization on the training set. The selected variables was fit to a logistic model to obtain regression coefficients. The performance of the final prediction model was evaluated by the area under the ROC curve in both training and testing sets.
Results:
The dataset was randomly separated into training [7606 (67 %) patients] and testing [3746 (33 %) patients] sets. The final model included: age (>65 years), gender (male), weight (kg), BMI, insurance status (yes/unknown), stage (IIIB/IV/ESSCLC), number of metastatic sites (1, 2 or ≥3), individual drugs (gemcitabine, taxanes), number of chemotherapy agents (2 or ≥3), planned use of growth factors, associated radiation therapy, previous therapy (chemotherapy, radiation, surgery), duration of planned treatment, pleural effusion (yes/unknown), performance status (1, ≥2) and presence of symptoms (yes/unknown).
Conclusions:
We have developed a relatively simple model with routinely available pre-treatment variables, to predict for neutropenia. This model should be independently validated prospectively. |
Persistent Identifier | http://hdl.handle.net/10722/281770 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.761 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, X | - |
dc.contributor.author | Ganti, AK | - |
dc.contributor.author | Stinchcombe, T | - |
dc.contributor.author | Wong, ML | - |
dc.contributor.author | Ho, JC | - |
dc.contributor.author | Shen, C | - |
dc.contributor.author | Liu, Y | - |
dc.contributor.author | Crawford, J | - |
dc.contributor.author | Pang, H | - |
dc.contributor.author | Wang, X | - |
dc.date.accessioned | 2020-03-27T04:22:20Z | - |
dc.date.available | 2020-03-27T04:22:20Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Lung Cancer, 2020, v. 141, p. 14-20 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | http://hdl.handle.net/10722/281770 | - |
dc.description.abstract | Objectives: Neutropenia is associated with the risk of life-threatening infections, chemotherapy dose reductions and delays that may compromise outcomes. This analysis was conducted to develop a prediction model for chemotherapy-induced severe neutropenia in lung cancer. Materials and Methods: Individual patient data from existing cooperative group phase II/III trials of stages III/IV non-small cell lung cancer or extensive small-cell lung cancer were included. The data were split into training and testing sets. In order to enhance the prediction accuracy and the reliability of the prediction model, lasso method was used for both variable selection and regularization on the training set. The selected variables was fit to a logistic model to obtain regression coefficients. The performance of the final prediction model was evaluated by the area under the ROC curve in both training and testing sets. Results: The dataset was randomly separated into training [7606 (67 %) patients] and testing [3746 (33 %) patients] sets. The final model included: age (>65 years), gender (male), weight (kg), BMI, insurance status (yes/unknown), stage (IIIB/IV/ESSCLC), number of metastatic sites (1, 2 or ≥3), individual drugs (gemcitabine, taxanes), number of chemotherapy agents (2 or ≥3), planned use of growth factors, associated radiation therapy, previous therapy (chemotherapy, radiation, surgery), duration of planned treatment, pleural effusion (yes/unknown), performance status (1, ≥2) and presence of symptoms (yes/unknown). Conclusions: We have developed a relatively simple model with routinely available pre-treatment variables, to predict for neutropenia. This model should be independently validated prospectively. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan | - |
dc.relation.ispartof | Lung Cancer | - |
dc.subject | Lung cancer | - |
dc.subject | Neutropenia | - |
dc.subject | Predictive models | - |
dc.title | Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer | - |
dc.type | Article | - |
dc.identifier.email | Ho, JC: jhocm@hku.hk | - |
dc.identifier.email | Pang, H: herbpang@hku.hk | - |
dc.identifier.authority | Ho, JC=rp00258 | - |
dc.identifier.authority | Pang, H=rp01857 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.lungcan.2020.01.004 | - |
dc.identifier.pmid | 31926983 | - |
dc.identifier.pmcid | PMC7063587 | - |
dc.identifier.scopus | eid_2-s2.0-85077657547 | - |
dc.identifier.hkuros | 309584 | - |
dc.identifier.volume | 141 | - |
dc.identifier.spage | 14 | - |
dc.identifier.epage | 20 | - |
dc.identifier.isi | WOS:000518489000003 | - |
dc.publisher.place | Ireland | - |
dc.identifier.issnl | 0169-5002 | - |