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Article: A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties

TitleA novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties
Authors
Keywordscalcium silicate
sol–gel
zinc magnesium
setting time
Issue Date2020
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2020, v. 108 n. 1, p. 56-66 How to Cite?
AbstractThe aim of the current study was to synthesize a fast‐setting ion‐doped calcium silicate bioceramic by the sol–gel method and to characterize its in vitro apatite‐forming ability and cell viability. Calcium silicate (CS), doped calcium silicate with zinc and magnesium, with Ca/Zn molar ratios of 6.7:1 (DCS1), and 4.5:1 (DCS2), were synthesized by the sol–gel method. Matreva white MTA (WMTA, Matreva, CA, Egypt) was used as a control. The synthesized powders were characterized by x‐ray diffraction. Setting time was measured using the Gilmore needle indentation technique. The in vitro apatite‐forming ability of the materials was evaluated by scanning electron microscope and energy dispersive X‐ray. NIH3T3‐E1 cells viability was tested using MTT assay. The ion release of Ca, Si, Zn, and Mg was measured using inductive coupled plasma‐optical emission spectroscopy (ICP‐OES). One‐way ANOVA was used to analyze setting time results. The Tukey's HSD post hoc test was used to establish significance (p < 0.001). For nonparametric data, the Kruskal–Wallis H test with Dunn's correction for post hoc comparison was used (p < 0.05). CS, DCS1, and DCS2 showed a significant decrease in setting time 33 ± 1.63 min, 28 ± 1.63 min, and 41.75 ± 2.87 min, respectively, compared to WMTA 91 ± 3.16 min (p < 0.001). DCS1 showed the highest apatite‐forming ability and cell viability compared to the other groups. Ca and Si ions release decreased in both DCS1 and DCS2. The physical and biological properties of CS can be successfully improved by the sol–gel synthesis and ions doping. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:56–66, 2020.
Persistent Identifierhttp://hdl.handle.net/10722/281784
ISSN
2020 Impact Factor: 3.368
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAbdalla, MM-
dc.contributor.authorLung, CYK-
dc.contributor.authorNeelakantan, P-
dc.contributor.authorMatinlinna, JP-
dc.date.accessioned2020-03-27T04:22:29Z-
dc.date.available2020-03-27T04:22:29Z-
dc.date.issued2020-
dc.identifier.citationJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2020, v. 108 n. 1, p. 56-66-
dc.identifier.issn1552-4973-
dc.identifier.urihttp://hdl.handle.net/10722/281784-
dc.description.abstractThe aim of the current study was to synthesize a fast‐setting ion‐doped calcium silicate bioceramic by the sol–gel method and to characterize its in vitro apatite‐forming ability and cell viability. Calcium silicate (CS), doped calcium silicate with zinc and magnesium, with Ca/Zn molar ratios of 6.7:1 (DCS1), and 4.5:1 (DCS2), were synthesized by the sol–gel method. Matreva white MTA (WMTA, Matreva, CA, Egypt) was used as a control. The synthesized powders were characterized by x‐ray diffraction. Setting time was measured using the Gilmore needle indentation technique. The in vitro apatite‐forming ability of the materials was evaluated by scanning electron microscope and energy dispersive X‐ray. NIH3T3‐E1 cells viability was tested using MTT assay. The ion release of Ca, Si, Zn, and Mg was measured using inductive coupled plasma‐optical emission spectroscopy (ICP‐OES). One‐way ANOVA was used to analyze setting time results. The Tukey's HSD post hoc test was used to establish significance (p < 0.001). For nonparametric data, the Kruskal–Wallis H test with Dunn's correction for post hoc comparison was used (p < 0.05). CS, DCS1, and DCS2 showed a significant decrease in setting time 33 ± 1.63 min, 28 ± 1.63 min, and 41.75 ± 2.87 min, respectively, compared to WMTA 91 ± 3.16 min (p < 0.001). DCS1 showed the highest apatite‐forming ability and cell viability compared to the other groups. Ca and Si ions release decreased in both DCS1 and DCS2. The physical and biological properties of CS can be successfully improved by the sol–gel synthesis and ions doping. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:56–66, 2020.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/-
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterials-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcalcium silicate-
dc.subjectsol–gel-
dc.subjectzinc magnesium-
dc.subjectsetting time-
dc.titleA novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties-
dc.typeArticle-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.emailMatinlinna, JP: jpmat@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.identifier.authorityMatinlinna, JP=rp00052-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.34365-
dc.identifier.pmid30920144-
dc.identifier.scopuseid_2-s2.0-85063564867-
dc.identifier.scopuseid_2-s2.0-85063564867-
dc.identifier.hkuros309502-
dc.identifier.hkuros315951-
dc.identifier.volume108-
dc.identifier.issue1-
dc.identifier.spage56-
dc.identifier.epage66-
dc.identifier.isiWOS:000500822700007-
dc.publisher.placeUnited States-
dc.identifier.issnl1552-4973-

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