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Article: A Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China

TitleA Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China
Authors
Keywordsenzootic nasal tumor virus
ENTV-2
novel variation
genetic diversity
goats
Issue Date2019
PublisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses
Citation
Viruses, 2019, v. 11 n. 10, p. article no. 956 How to Cite?
AbstractEnzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2.
Persistent Identifierhttp://hdl.handle.net/10722/281888
ISSN
2018 Impact Factor: 3.811
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhai, SL-
dc.contributor.authorLv, D-H-
dc.contributor.authorXu, Z-H-
dc.contributor.authorYu, J-S-
dc.contributor.authorWen, X-H-
dc.contributor.authorZhang, H-
dc.contributor.authorChen, Q-L-
dc.contributor.authorJia, C-L-
dc.contributor.authorZhou, X-R-
dc.contributor.authorZhai, Q-
dc.contributor.authorLi, F-
dc.contributor.authorWoo, PCY-
dc.contributor.authorLau, SKP-
dc.contributor.authorWang, D-
dc.contributor.authorWei, W-K-
dc.date.accessioned2020-04-03T07:23:11Z-
dc.date.available2020-04-03T07:23:11Z-
dc.date.issued2019-
dc.identifier.citationViruses, 2019, v. 11 n. 10, p. article no. 956-
dc.identifier.issn1999-4915-
dc.identifier.urihttp://hdl.handle.net/10722/281888-
dc.description.abstractEnzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses-
dc.relation.ispartofViruses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectenzootic nasal tumor virus-
dc.subjectENTV-2-
dc.subjectnovel variation-
dc.subjectgenetic diversity-
dc.subjectgoats-
dc.titleA Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China-
dc.typeArticle-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.authorityLau, SKP=rp00486-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/v11100956-
dc.identifier.pmid31627264-
dc.identifier.pmcidPMC6832284-
dc.identifier.scopuseid_2-s2.0-85073634466-
dc.identifier.hkuros309638-
dc.identifier.volume11-
dc.identifier.issue10-
dc.identifier.spagearticle no. 956-
dc.identifier.epagearticle no. 956-
dc.identifier.isiWOS:000498400400077-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1999-4915-

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