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Article: National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries
Title | National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries |
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Authors | |
Keywords | Total cholesterol LDL cholesterol HDL cholesterol blood lipids multi-country study |
Issue Date | 2020 |
Publisher | Oxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/ |
Citation | International Journal of Epidemiology, 2020, v. 49 n. 1, p. 173-192 How to Cite? |
Abstract | Background:
Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.
Methods:
We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.
Results:
Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.
Conclusions:
HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. |
Persistent Identifier | http://hdl.handle.net/10722/282820 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 2.663 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, TH | - |
dc.contributor.author | NCD Risk Factor Collaboration (NCD-RisC) | - |
dc.date.accessioned | 2020-06-05T06:21:57Z | - |
dc.date.available | 2020-06-05T06:21:57Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Epidemiology, 2020, v. 49 n. 1, p. 173-192 | - |
dc.identifier.issn | 0300-5771 | - |
dc.identifier.uri | http://hdl.handle.net/10722/282820 | - |
dc.description.abstract | Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/ | - |
dc.relation.ispartof | International Journal of Epidemiology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Total cholesterol | - |
dc.subject | LDL cholesterol | - |
dc.subject | HDL cholesterol | - |
dc.subject | blood lipids | - |
dc.subject | multi-country study | - |
dc.title | National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries | - |
dc.type | Article | - |
dc.identifier.email | Lam, TH: hrmrlth@hkucc.hku.hk | - |
dc.identifier.authority | Lam, TH=rp00326 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1093/ije/dyz099 | - |
dc.identifier.pmid | 31321439 | - |
dc.identifier.pmcid | PMC7245049 | - |
dc.identifier.scopus | eid_2-s2.0-85074478745 | - |
dc.identifier.hkuros | 310147 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 173 | - |
dc.identifier.epage | 192 | - |
dc.identifier.isi | WOS:000536507900023 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0300-5771 | - |