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Article: Effect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial

TitleEffect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial
Authors
KeywordsLingqi Huangban granule
Intravitreal injections
Ranibizumab
Macular edema
Retinal vein occlusion
Issue Date2020
PublisherThe China Association of Chinese Medicine/Chinese Academy of Chinese Medical Sciences. The Journal's web site is located at http://www.journaltcm.com
Citation
Journal of Traditional Chinese Medicine, 2020, v. 40 n. 2, p. 305-310 How to Cite?
AbstractOBJECTIVE: To investigate the effect of Lingqi Huangban granule (LQHB) plus intravitreal ranibizumab in the treatment of macular edema (ME) induced by retinal vein occlusion (RVO). METHODS: A prospective, randomized controlled study was conducted. A total of 60 subjects with RVO induced ME were randomized into control group (CG) (30 eyes) and LQHB group (LQHBG) (30 eyes). CG patients underwent intravitreal ranibizumab (IVR) injections. LQHBG patients were treated with oral LQHB combined with IVR injections. In order to reduce the financial burden of the injections, we used one injection and pro re nata (PRN) regimen for both groups. The best-corrected visual acuity (BCVA), central macular thickness (CMT), and mean number of injections were evaluated at the beginning of treatment and 3, 6, 9 and 12 months afterward. All the subjects were followed up for 1 year. RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients (P > 0.05). At 3, 6, 9 and 12 months after treatment, however, the BCVA scores improved and the CMT measurements decreased in all patients (P < 0.05), with the improvement of LQHBG significantly greater than that of CG (P < 0.05). The mean numbers of ranibizumab injections were 1.8 ± 0.3 in LQHBG and 2.3 ± 0.6 in CG, respectively (P < 0.05). No adverse events were reported in both groups. CONCLUSION: LQHB plus intravitreal ranibizumab could be a much more effective and economic treatment for stabilizing and improving vision with fewer intravitreal injections in the treatment of RVO induced ME. This integrative therapy appears to be a promising option for this type of patient.
Persistent Identifierhttp://hdl.handle.net/10722/283035
ISSN
2023 Impact Factor: 2.0
2023 SCImago Journal Rankings: 0.363

 

DC FieldValueLanguage
dc.contributor.authorLu, B-
dc.contributor.authorWu, X-
dc.date.accessioned2020-06-05T06:24:14Z-
dc.date.available2020-06-05T06:24:14Z-
dc.date.issued2020-
dc.identifier.citationJournal of Traditional Chinese Medicine, 2020, v. 40 n. 2, p. 305-310-
dc.identifier.issn0255-2922-
dc.identifier.urihttp://hdl.handle.net/10722/283035-
dc.description.abstractOBJECTIVE: To investigate the effect of Lingqi Huangban granule (LQHB) plus intravitreal ranibizumab in the treatment of macular edema (ME) induced by retinal vein occlusion (RVO). METHODS: A prospective, randomized controlled study was conducted. A total of 60 subjects with RVO induced ME were randomized into control group (CG) (30 eyes) and LQHB group (LQHBG) (30 eyes). CG patients underwent intravitreal ranibizumab (IVR) injections. LQHBG patients were treated with oral LQHB combined with IVR injections. In order to reduce the financial burden of the injections, we used one injection and pro re nata (PRN) regimen for both groups. The best-corrected visual acuity (BCVA), central macular thickness (CMT), and mean number of injections were evaluated at the beginning of treatment and 3, 6, 9 and 12 months afterward. All the subjects were followed up for 1 year. RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients (P > 0.05). At 3, 6, 9 and 12 months after treatment, however, the BCVA scores improved and the CMT measurements decreased in all patients (P < 0.05), with the improvement of LQHBG significantly greater than that of CG (P < 0.05). The mean numbers of ranibizumab injections were 1.8 ± 0.3 in LQHBG and 2.3 ± 0.6 in CG, respectively (P < 0.05). No adverse events were reported in both groups. CONCLUSION: LQHB plus intravitreal ranibizumab could be a much more effective and economic treatment for stabilizing and improving vision with fewer intravitreal injections in the treatment of RVO induced ME. This integrative therapy appears to be a promising option for this type of patient. -
dc.languageeng-
dc.publisherThe China Association of Chinese Medicine/Chinese Academy of Chinese Medical Sciences. The Journal's web site is located at http://www.journaltcm.com-
dc.relation.ispartofJournal of Traditional Chinese Medicine-
dc.subjectLingqi Huangban granule-
dc.subjectIntravitreal injections-
dc.subjectRanibizumab-
dc.subjectMacular edema-
dc.subjectRetinal vein occlusion-
dc.titleEffect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial-
dc.typeArticle-
dc.identifier.emailLu, B: willalu@hku.hk-
dc.identifier.hkuros310187-
dc.identifier.volume40-
dc.identifier.issue2-
dc.identifier.spage305-
dc.identifier.epage310-
dc.publisher.placeChina-
dc.identifier.issnl0255-2922-

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