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Article: Differences in omega-5-gliadin allergy: East versus West

TitleDifferences in omega-5-gliadin allergy: East versus West
Authors
KeywordsAllergy
Wheat
Cofactor
Food
Anaphylaxis
Issue Date2020
PublisherAsia Pacific Association of Allergy, Asthma and Clinical Immunology. The Journal's web site is located at http://www.apallergy.org/
Citation
Asia Pacific Allergy, 2020, v. 10 n. 1, p. article no. e5 How to Cite?
AbstractBackground: Omega-5-gliadin (O5G) allergy, also known as wheat-dependent exercise-induced anaphylaxis, is commonly reported in the Western, but not Asian, populations. Although significant differences in O5G allergy presentation across different populations are likely but there have been no previous reports on this important topic. Objective: To report on the prevalence and characteristics of O5G allergy in Hong Kong (HK) compared with the United Kingdom (UK). Methods: O5G allergy patients attending Queen Mary Hospital (HK cohort), and Guy's and St Thomas' Hospital, London (UK cohort) were studied and compared. Results: A total of 46 O5G allergy patients (16 HK; 30 UK) were studied. In the HK cohort, 55% of all patients previously labeled as “idiopathic anaphylaxis” were diagnosed with O5G allergy. Exercise was the most common cofactor in both cohorts, followed by alcohol and nonsteroidal anti-inflammatory drugs (NSAID). A higher proportion of the HK cohort reported NSAID as a cofactor (13% vs. 0%, p = 0.048). In the HK cohort, more patients presented with urticaria and cardiovascular manifestations (100% vs. 77%, p = 0.036; 100% vs. 70%, p = 0.015, respectively); the range of presentation was more diverse in the UK cohort. In HK fewer patients adhered to wheat avoidance (50% vs. 87%, p = 0.007) and more patients avoided cofactors only (44% vs. 10%, p = 0.008). Conclusion: O5G allergy appears relatively underdiagnosed in HK. Urticaria and cardiovascular manifestations are common; NSAID plays an important role as a cofactor and patients are less concordant with dietary avoidance measures than in the Western population.
Persistent Identifierhttp://hdl.handle.net/10722/283258
ISSN
2020 SCImago Journal Rankings: 0.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, PH-
dc.contributor.authorThomas, I-
dc.contributor.authorWong, JCY-
dc.contributor.authorRutkowski, K-
dc.contributor.authorLi, PH-
dc.date.accessioned2020-06-22T02:54:14Z-
dc.date.available2020-06-22T02:54:14Z-
dc.date.issued2020-
dc.identifier.citationAsia Pacific Allergy, 2020, v. 10 n. 1, p. article no. e5-
dc.identifier.issn2233-8276-
dc.identifier.urihttp://hdl.handle.net/10722/283258-
dc.description.abstractBackground: Omega-5-gliadin (O5G) allergy, also known as wheat-dependent exercise-induced anaphylaxis, is commonly reported in the Western, but not Asian, populations. Although significant differences in O5G allergy presentation across different populations are likely but there have been no previous reports on this important topic. Objective: To report on the prevalence and characteristics of O5G allergy in Hong Kong (HK) compared with the United Kingdom (UK). Methods: O5G allergy patients attending Queen Mary Hospital (HK cohort), and Guy's and St Thomas' Hospital, London (UK cohort) were studied and compared. Results: A total of 46 O5G allergy patients (16 HK; 30 UK) were studied. In the HK cohort, 55% of all patients previously labeled as “idiopathic anaphylaxis” were diagnosed with O5G allergy. Exercise was the most common cofactor in both cohorts, followed by alcohol and nonsteroidal anti-inflammatory drugs (NSAID). A higher proportion of the HK cohort reported NSAID as a cofactor (13% vs. 0%, p = 0.048). In the HK cohort, more patients presented with urticaria and cardiovascular manifestations (100% vs. 77%, p = 0.036; 100% vs. 70%, p = 0.015, respectively); the range of presentation was more diverse in the UK cohort. In HK fewer patients adhered to wheat avoidance (50% vs. 87%, p = 0.007) and more patients avoided cofactors only (44% vs. 10%, p = 0.008). Conclusion: O5G allergy appears relatively underdiagnosed in HK. Urticaria and cardiovascular manifestations are common; NSAID plays an important role as a cofactor and patients are less concordant with dietary avoidance measures than in the Western population.-
dc.languageeng-
dc.publisherAsia Pacific Association of Allergy, Asthma and Clinical Immunology. The Journal's web site is located at http://www.apallergy.org/-
dc.relation.ispartofAsia Pacific Allergy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAllergy-
dc.subjectWheat-
dc.subjectCofactor-
dc.subjectFood-
dc.subjectAnaphylaxis-
dc.titleDifferences in omega-5-gliadin allergy: East versus West-
dc.typeArticle-
dc.identifier.emailLi, PH: liphilip@HKUCC-COM.hku.hk-
dc.identifier.emailLi, PH: liphilip@HKUCC-COM.hku.hk-
dc.identifier.authorityLi, PH=rp02669-
dc.identifier.authorityLi, PH=rp02669-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5415/apallergy.2020.10.e5-
dc.identifier.pmid32099827-
dc.identifier.pmcidPMC7016325-
dc.identifier.hkuros310338-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spagearticle no. e5-
dc.identifier.epagearticle no. e5-
dc.identifier.isiWOS:000514547700005-
dc.publisher.placeKorea, Republic of-
dc.identifier.issnl2233-8276-

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