File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Dietary Fiber from Oat and Rye Brans Ameliorate Western Diet-Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short-Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism

TitleDietary Fiber from Oat and Rye Brans Ameliorate Western Diet-Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short-Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism
Authors
Keywordsdietary fiber
gut metabolism
microbial metabolites
obesity
prebiotics
Issue Date2020
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133
Citation
Molecular Nutrition & Food Research, 2020, Epub 2020-06-11, p. article no. 1900580 How to Cite?
AbstractScope: Dietary fiber (DF) induces changes in gut microbiota function and thus modulates the gut environment. How this modulation is associated with metabolic pathways related to the gut is largely unclear. This study aims to investigate differences in metabolites produced by the gut microbiota and their interactions with host metabolism in response to supplementation with two bran fibers. Methods and Results: Male C57BL/6N mice are fed a western diet (WD) for 17 weeks. Two groups of mice received a diet enriched with 10% w/w of either oat or rye bran, with each bran containing 50% DF. Microbial metabolites are assessed by measuring cecal short‐chain fatty acids (SCFAs), ileal and fecal bile acids (BAs), and the expression of genes related to tryptophan (TRP) metabolism. Both brans lowered body weight gain and ameliorated WD‐induced impaired glucose responses, hepatic inflammation, liver enzymes, and gut integrity markers associated with SCFA production, altered BA metabolism, and TRP diversion from the serotonin synthesis pathway to microbial indole production. Conclusions: Both brans develop a favorable environment in the gut by altering the composition of microbes and modulating produced metabolites. Changes induced in the gut environment by a fiber‐enriched diet may explain the amelioration of metabolic disturbances related to WD.
Persistent Identifierhttp://hdl.handle.net/10722/283323
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.039
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKUNDI, ZM-
dc.contributor.authorLee, JCY-
dc.contributor.authorPihlajamäki, J-
dc.contributor.authorChan, CB-
dc.contributor.authorLeung, KS-
dc.contributor.authorSO, SSY-
dc.contributor.authorNordlund, E-
dc.contributor.authorKolehmainen, M-
dc.contributor.authorEl-Nezamy, H-
dc.date.accessioned2020-06-22T02:55:01Z-
dc.date.available2020-06-22T02:55:01Z-
dc.date.issued2020-
dc.identifier.citationMolecular Nutrition & Food Research, 2020, Epub 2020-06-11, p. article no. 1900580-
dc.identifier.issn1613-4125-
dc.identifier.urihttp://hdl.handle.net/10722/283323-
dc.description.abstractScope: Dietary fiber (DF) induces changes in gut microbiota function and thus modulates the gut environment. How this modulation is associated with metabolic pathways related to the gut is largely unclear. This study aims to investigate differences in metabolites produced by the gut microbiota and their interactions with host metabolism in response to supplementation with two bran fibers. Methods and Results: Male C57BL/6N mice are fed a western diet (WD) for 17 weeks. Two groups of mice received a diet enriched with 10% w/w of either oat or rye bran, with each bran containing 50% DF. Microbial metabolites are assessed by measuring cecal short‐chain fatty acids (SCFAs), ileal and fecal bile acids (BAs), and the expression of genes related to tryptophan (TRP) metabolism. Both brans lowered body weight gain and ameliorated WD‐induced impaired glucose responses, hepatic inflammation, liver enzymes, and gut integrity markers associated with SCFA production, altered BA metabolism, and TRP diversion from the serotonin synthesis pathway to microbial indole production. Conclusions: Both brans develop a favorable environment in the gut by altering the composition of microbes and modulating produced metabolites. Changes induced in the gut environment by a fiber‐enriched diet may explain the amelioration of metabolic disturbances related to WD.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133-
dc.relation.ispartofMolecular Nutrition & Food Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdietary fiber-
dc.subjectgut metabolism-
dc.subjectmicrobial metabolites-
dc.subjectobesity-
dc.subjectprebiotics-
dc.titleDietary Fiber from Oat and Rye Brans Ameliorate Western Diet-Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short-Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism-
dc.typeArticle-
dc.identifier.emailLee, JCY: jettylee@hku.hk-
dc.identifier.emailChan, CB: chancb@hku.hk-
dc.identifier.emailLeung, KS: lks612@hku.hk-
dc.identifier.emailEl-Nezamy, H: elnezami@hkucc.hku.hk-
dc.identifier.authorityLee, JCY=rp01511-
dc.identifier.authorityChan, CB=rp02140-
dc.identifier.authorityEl-Nezamy, H=rp00694-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/mnfr.201900580-
dc.identifier.scopuseid_2-s2.0-85087116168-
dc.identifier.hkuros310445-
dc.identifier.volumeEpub 2020-06-11-
dc.identifier.spagearticle no. 1900580-
dc.identifier.epagearticle no. 1900580-
dc.identifier.isiWOS:000541457300001-
dc.publisher.placeGermany-
dc.identifier.issnl1613-4125-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats