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Article: Enhancement of Hippocampal Plasticity by Physical Exercise as a Polypill for Stress and Depression: A Review

TitleEnhancement of Hippocampal Plasticity by Physical Exercise as a Polypill for Stress and Depression: A Review
Authors
KeywordsPhysical exercise
stress, depression
hippocampal neurogenesis
dendritic remodeling
synaptic plasticity
Issue Date2019
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd
Citation
CNS & Neurological Disorders - Drug Targets, 2019, v. 18 n. 4, p. 294-306 How to Cite?
AbstractGeneration of newborn neurons that form functional synaptic connections in the dentate gyrus of adult mammals, known as adult hippocampal neurogenesis, has been suggested to play critical roles in regulating mood, as well as certain forms of hippocampus-dependent learning and memory. Environmental stress suppresses structural plasticity including adult neurogenesis and dendritic remodeling in the hippocampus, whereas physical exercise exerts opposite effects. Here, we review recent discoveries on the potential mechanisms concerning how physical exercise mitigates the stressrelated depressive disorders, with a focus on the perspective of modulation on hippocampal neurogenesis, dendritic remodeling and synaptic plasticity. Unmasking such mechanisms may help devise new drugs in the future for treating neuropsychiatric disorders involving impaired neural plasticity.
Persistent Identifierhttp://hdl.handle.net/10722/283697
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.620
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, A-
dc.contributor.authorYau, SY-
dc.contributor.authorMachado, S-
dc.contributor.authorWang, P-
dc.contributor.authorYuan, TF-
dc.contributor.authorSo, KF-
dc.date.accessioned2020-07-03T08:22:50Z-
dc.date.available2020-07-03T08:22:50Z-
dc.date.issued2019-
dc.identifier.citationCNS & Neurological Disorders - Drug Targets, 2019, v. 18 n. 4, p. 294-306-
dc.identifier.issn1871-5273-
dc.identifier.urihttp://hdl.handle.net/10722/283697-
dc.description.abstractGeneration of newborn neurons that form functional synaptic connections in the dentate gyrus of adult mammals, known as adult hippocampal neurogenesis, has been suggested to play critical roles in regulating mood, as well as certain forms of hippocampus-dependent learning and memory. Environmental stress suppresses structural plasticity including adult neurogenesis and dendritic remodeling in the hippocampus, whereas physical exercise exerts opposite effects. Here, we review recent discoveries on the potential mechanisms concerning how physical exercise mitigates the stressrelated depressive disorders, with a focus on the perspective of modulation on hippocampal neurogenesis, dendritic remodeling and synaptic plasticity. Unmasking such mechanisms may help devise new drugs in the future for treating neuropsychiatric disorders involving impaired neural plasticity.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd-
dc.relation.ispartofCNS & Neurological Disorders - Drug Targets-
dc.subjectPhysical exercise-
dc.subjectstress, depression-
dc.subjecthippocampal neurogenesis-
dc.subjectdendritic remodeling-
dc.subjectsynaptic plasticity-
dc.titleEnhancement of Hippocampal Plasticity by Physical Exercise as a Polypill for Stress and Depression: A Review-
dc.typeArticle-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1871527318666190308102804-
dc.identifier.pmid30848219-
dc.identifier.scopuseid_2-s2.0-85070759667-
dc.identifier.hkuros310723-
dc.identifier.volume18-
dc.identifier.issue4-
dc.identifier.spage294-
dc.identifier.epage306-
dc.identifier.isiWOS:000475802200005-
dc.publisher.placeNetherlands-
dc.identifier.issnl1871-5273-

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