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- Publisher Website: 10.1021/acs.jmedchem.9b01078
- Scopus: eid_2-s2.0-85074939521
- PMID: 31657913
- WOS: WOS:000500420100030
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Article: A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d-Stereoselective Peptidases
Title | A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d-Stereoselective Peptidases |
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Authors | |
Keywords | Lipids Peptides and proteins Antimicrobial activity Hydrolysis Assays |
Issue Date | 2019 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmc |
Citation | Journal of Medicinal Chemistry, 2019, v. 62 n. 22, p. 10466-10472 How to Cite? |
Abstract | D-Stereoselective peptidases that degrade nonribosomal peptides (NRPs) were recently discovered and could have serious implications for the future of NRPs as antibiotics. Herein, we report chemical modifications that can be used to impart resistance to the d-peptidases BogQ and TriF. New tridecaptin A analogues were synthesized that retain strong antimicrobial activity and have significantly enhanced d-peptidase stability. Invitro assays confirmed that synthetic analogues retain the ability to bind to their cellular receptor, peptidoglycan intermediate lipid II. |
Persistent Identifier | http://hdl.handle.net/10722/284013 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 1.986 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bann, SJ | - |
dc.contributor.author | Ballantine, RD | - |
dc.contributor.author | McCallion, CE | - |
dc.contributor.author | Qian, PY | - |
dc.contributor.author | Li, YX | - |
dc.contributor.author | Cochrane, SA | - |
dc.date.accessioned | 2020-07-20T05:55:19Z | - |
dc.date.available | 2020-07-20T05:55:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Medicinal Chemistry, 2019, v. 62 n. 22, p. 10466-10472 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284013 | - |
dc.description.abstract | D-Stereoselective peptidases that degrade nonribosomal peptides (NRPs) were recently discovered and could have serious implications for the future of NRPs as antibiotics. Herein, we report chemical modifications that can be used to impart resistance to the d-peptidases BogQ and TriF. New tridecaptin A analogues were synthesized that retain strong antimicrobial activity and have significantly enhanced d-peptidase stability. Invitro assays confirmed that synthetic analogues retain the ability to bind to their cellular receptor, peptidoglycan intermediate lipid II. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmc | - |
dc.relation.ispartof | Journal of Medicinal Chemistry | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Lipids | - |
dc.subject | Peptides and proteins | - |
dc.subject | Antimicrobial activity | - |
dc.subject | Hydrolysis | - |
dc.subject | Assays | - |
dc.title | A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d-Stereoselective Peptidases | - |
dc.type | Article | - |
dc.identifier.email | Li, YX: yxpli@hku.hk | - |
dc.identifier.authority | Li, YX=rp02556 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1021/acs.jmedchem.9b01078 | - |
dc.identifier.pmid | 31657913 | - |
dc.identifier.pmcid | PMC6887851 | - |
dc.identifier.scopus | eid_2-s2.0-85074939521 | - |
dc.identifier.hkuros | 310994 | - |
dc.identifier.volume | 62 | - |
dc.identifier.issue | 22 | - |
dc.identifier.spage | 10466 | - |
dc.identifier.epage | 10472 | - |
dc.identifier.isi | WOS:000500420100030 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-2623 | - |