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- Publisher Website: 10.1002/anie.202005429
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- PMID: 32472602
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Article: A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals
Title | A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals |
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Authors | |
Keywords | bioimaging chemiluminescence hydrogen peroxide imaging agents fluorescent probes |
Issue Date | 2020 |
Publisher | Wiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773 |
Citation | Angewandte Chemie (International Edition), 2020, v. 59 n. 34, p. 14326-14330 How to Cite? |
Abstract | Selective and sensitive molecular probes for hydrogen peroxide (H2O2), which plays diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the physiological and pathological effects of H2O2. A lack of reliable tools for in vivo imaging has hampered the development of H2O2 mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H2O2‐CL‐510 was developed as a highly selective and sensitive probe for detection of H2O2 both in vitro and in vivo. A rapid 430‐fold enhancement of chemiluminescence was triggered directly by H2O2 without any laser excitation. Arsenic trioxide induced oxidative damage in leukemia was successfully detected. In particular, cerebral ischemia‐reperfusion injury‐induced H2O2 fluxes were visualized in rat brains using H2O2‐CL‐510 , providing a new chemical tool for real‐time monitoring of H2O2 dynamics in living animals. |
Persistent Identifier | http://hdl.handle.net/10722/284017 |
ISSN | 2023 Impact Factor: 16.1 2023 SCImago Journal Rankings: 5.300 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ye, S | - |
dc.contributor.author | Hananya, N | - |
dc.contributor.author | Green, O | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Zhao, AQ | - |
dc.contributor.author | Shen, J | - |
dc.contributor.author | Shabat, D | - |
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2020-07-20T05:55:21Z | - |
dc.date.available | 2020-07-20T05:55:21Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Angewandte Chemie (International Edition), 2020, v. 59 n. 34, p. 14326-14330 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284017 | - |
dc.description.abstract | Selective and sensitive molecular probes for hydrogen peroxide (H2O2), which plays diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the physiological and pathological effects of H2O2. A lack of reliable tools for in vivo imaging has hampered the development of H2O2 mediated therapeutics. By combining a specific tandem Payne/Dakin reaction with a chemiluminescent scaffold, H2O2‐CL‐510 was developed as a highly selective and sensitive probe for detection of H2O2 both in vitro and in vivo. A rapid 430‐fold enhancement of chemiluminescence was triggered directly by H2O2 without any laser excitation. Arsenic trioxide induced oxidative damage in leukemia was successfully detected. In particular, cerebral ischemia‐reperfusion injury‐induced H2O2 fluxes were visualized in rat brains using H2O2‐CL‐510 , providing a new chemical tool for real‐time monitoring of H2O2 dynamics in living animals. | - |
dc.language | eng | - |
dc.publisher | Wiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773 | - |
dc.relation.ispartof | Angewandte Chemie (International Edition) | - |
dc.rights | This is the peer reviewed version of the following article: Angewandte Chemie (International Edition), 2020, v. 59 n. 34, p. 14326-14330, which has been published in final form at https://doi.org/10.1002/anie.202005429. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | bioimaging | - |
dc.subject | chemiluminescence | - |
dc.subject | hydrogen peroxide | - |
dc.subject | imaging agents | - |
dc.subject | fluorescent probes | - |
dc.title | A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals | - |
dc.type | Article | - |
dc.identifier.email | Ye, S: yesen@hku.hk | - |
dc.identifier.email | Shen, J: shenjg@hku.hk | - |
dc.identifier.email | Yang, D: yangdan@hku.hk | - |
dc.identifier.authority | Ye, S=rp02805 | - |
dc.identifier.authority | Shen, J=rp00487 | - |
dc.identifier.authority | Yang, D=rp00825 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1002/anie.202005429 | - |
dc.identifier.pmid | 32472602 | - |
dc.identifier.scopus | eid_2-s2.0-85087182086 | - |
dc.identifier.hkuros | 311044 | - |
dc.identifier.volume | 59 | - |
dc.identifier.issue | 34 | - |
dc.identifier.spage | 14326 | - |
dc.identifier.epage | 14330 | - |
dc.identifier.isi | WOS:000544371100001 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 1433-7851 | - |