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Article: Prognostic significance of multi‐positive invasive histopathology in oral cancer

TitlePrognostic significance of multi‐positive invasive histopathology in oral cancer
Authors
Keywordsoral cancer
oral mucosa
Issue Date2020
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714
Citation
Journal of Oral Pathology & Medicine, 2020, Epub 2020-08-02 How to Cite?
AbstractBackground: Oral squamous cell carcinoma (OSCC) is a lethal and deforming disease of rising incidence. With poor 5‐year survival rates associated with higher stage disease, there is a need in clinical practice for reliable prognostic determinants to consolidate treatment planning and coordinate therapeutic approaches to improve long‐term clinical outcomes for patients. Methods: A retrospective clinicopathological review of 467 OSCC patients with documented clinical outcome and treated in Hong Kong over a 19‐year period was undertaken to investigate the potential prognostic role of 4 specific histopathological features of invasive tumour behaviour: perineural invasion (PNI), bone invasion (BNI), lymphovascular invasion (LVI) and extra‐nodal extension (ENE) in metastatic neck disease. Results: Histopathological data for PNI, BNI, LVI and ENE, and stratified as zero, one, two, three or four positives, were available for 279 patients. A trend for decreased disease‐free status was seen with increasing numbers of positive histopathological features, although this was not statistically significant (P = .1076). The time to onset of further disease (loco‐regional recurrence and/or distant metastasis) was statistically significant, however, with progressive disease presenting most rapidly with increasing numbers of positive invasive parameters (P = .000152). Conclusion: PNI, BNI, LVI and ENE, especially when found in combination, show promise as prognostic markers of poor clinical outcome following OSCC treatment. Further, multi‐centre prospective studies are required to confirm the predictive value of multi‐positive histopathological features in clinical practice and to help improve individualised treatment planning.
Persistent Identifierhttp://hdl.handle.net/10722/284522
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorADEOYE, J-
dc.contributor.authorThomson, P-
dc.contributor.authorChoi, SW-
dc.date.accessioned2020-08-07T08:58:51Z-
dc.date.available2020-08-07T08:58:51Z-
dc.date.issued2020-
dc.identifier.citationJournal of Oral Pathology & Medicine, 2020, Epub 2020-08-02-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/284522-
dc.description.abstractBackground: Oral squamous cell carcinoma (OSCC) is a lethal and deforming disease of rising incidence. With poor 5‐year survival rates associated with higher stage disease, there is a need in clinical practice for reliable prognostic determinants to consolidate treatment planning and coordinate therapeutic approaches to improve long‐term clinical outcomes for patients. Methods: A retrospective clinicopathological review of 467 OSCC patients with documented clinical outcome and treated in Hong Kong over a 19‐year period was undertaken to investigate the potential prognostic role of 4 specific histopathological features of invasive tumour behaviour: perineural invasion (PNI), bone invasion (BNI), lymphovascular invasion (LVI) and extra‐nodal extension (ENE) in metastatic neck disease. Results: Histopathological data for PNI, BNI, LVI and ENE, and stratified as zero, one, two, three or four positives, were available for 279 patients. A trend for decreased disease‐free status was seen with increasing numbers of positive histopathological features, although this was not statistically significant (P = .1076). The time to onset of further disease (loco‐regional recurrence and/or distant metastasis) was statistically significant, however, with progressive disease presenting most rapidly with increasing numbers of positive invasive parameters (P = .000152). Conclusion: PNI, BNI, LVI and ENE, especially when found in combination, show promise as prognostic markers of poor clinical outcome following OSCC treatment. Further, multi‐centre prospective studies are required to confirm the predictive value of multi‐positive histopathological features in clinical practice and to help improve individualised treatment planning.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectoral cancer-
dc.subjectoral mucosa-
dc.titlePrognostic significance of multi‐positive invasive histopathology in oral cancer-
dc.typeArticle-
dc.identifier.emailThomson, P: thomsonp@hku.hk-
dc.identifier.emailChoi, SW: htswchoi@hku.hk-
dc.identifier.authorityThomson, P=rp02327-
dc.identifier.authorityChoi, SW=rp02552-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jop.13086-
dc.identifier.pmid32740985-
dc.identifier.scopuseid_2-s2.0-85089604427-
dc.identifier.hkuros312459-
dc.identifier.volumeEpub 2020-08-02-
dc.identifier.isiWOS:000563921400001-
dc.publisher.placeDenmark-
dc.identifier.issnl0904-2512-

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