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Article: Enantiomer-specific bioaccumulation and distribution of chiral pharmaceuticals in a subtropical marine food web

TitleEnantiomer-specific bioaccumulation and distribution of chiral pharmaceuticals in a subtropical marine food web
Authors
KeywordsEnantioselectivity
Atenolol
Chloramphenicol
Trophic dilution
Risk assessment
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhazmat
Citation
Journal of Hazardous Materials, 2020, v. 394, p. article no. 122589 How to Cite?
AbstractThere is a growing concern about the occurrence of chiral pharmaceuticals in the aquatic environment. However, trophic transfer of pharmaceutical enantiomers in marine organisms is still largely unknown. This study assessed the bioaccumulation and spatial distribution of four frequently detected pharmaceuticals — atenolol, metoprolol, venlafaxine, and chloramphenicol, in a subtropical marine food web in Hong Kong waters. Twenty-four species were analyzed, including mollusks, crustaceans, and fishes. Special focus was placed in the chirality of the four analytes comprising ten different stereoisomers. Results showed that mean concentrations of individual pharmaceuticals ranged from <0.03 to 5.88 ng/g wet weight, and invertebrates generally had higher concentrations than fishes. Organisms from Hong Kong western waters were likely more contaminated by the studied pharmaceuticals than those from southern and eastern waters. Trophic dilution was observed for atenolol and chloramphenicol, with trophic magnification factors of 0.164 and 0.517, respectively. R-(+)-atenolol, S-(−)-metoprolol, and R-(−)-venlafaxine were selectively accumulated in fishes, and stereoisomeric impurities of chloramphenicol, i.e., enantiomers apart from R,R-para-form, were widespread in the investigated species. Under the worst-case scenario, atenolol and metoprolol in collected fishes might exceed toxic threshold, while local adults were unlikely to experience health risks from pharmaceutical exposure via seafood consumption.
Persistent Identifierhttp://hdl.handle.net/10722/284710
ISSN
2020 Impact Factor: 10.588
2015 SCImago Journal Rankings: 1.692
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRuan, YF-
dc.contributor.authorLin, H-
dc.contributor.authorZhang, X-
dc.contributor.authorWu, R-
dc.contributor.authorZhang, K-
dc.contributor.authorLeung, KMY-
dc.contributor.authorLam, JCW-
dc.contributor.authorLam, PKS-
dc.date.accessioned2020-08-07T09:01:37Z-
dc.date.available2020-08-07T09:01:37Z-
dc.date.issued2020-
dc.identifier.citationJournal of Hazardous Materials, 2020, v. 394, p. article no. 122589-
dc.identifier.issn0304-3894-
dc.identifier.urihttp://hdl.handle.net/10722/284710-
dc.description.abstractThere is a growing concern about the occurrence of chiral pharmaceuticals in the aquatic environment. However, trophic transfer of pharmaceutical enantiomers in marine organisms is still largely unknown. This study assessed the bioaccumulation and spatial distribution of four frequently detected pharmaceuticals — atenolol, metoprolol, venlafaxine, and chloramphenicol, in a subtropical marine food web in Hong Kong waters. Twenty-four species were analyzed, including mollusks, crustaceans, and fishes. Special focus was placed in the chirality of the four analytes comprising ten different stereoisomers. Results showed that mean concentrations of individual pharmaceuticals ranged from <0.03 to 5.88 ng/g wet weight, and invertebrates generally had higher concentrations than fishes. Organisms from Hong Kong western waters were likely more contaminated by the studied pharmaceuticals than those from southern and eastern waters. Trophic dilution was observed for atenolol and chloramphenicol, with trophic magnification factors of 0.164 and 0.517, respectively. R-(+)-atenolol, S-(−)-metoprolol, and R-(−)-venlafaxine were selectively accumulated in fishes, and stereoisomeric impurities of chloramphenicol, i.e., enantiomers apart from R,R-para-form, were widespread in the investigated species. Under the worst-case scenario, atenolol and metoprolol in collected fishes might exceed toxic threshold, while local adults were unlikely to experience health risks from pharmaceutical exposure via seafood consumption.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhazmat-
dc.relation.ispartofJournal of Hazardous Materials-
dc.subjectEnantioselectivity-
dc.subjectAtenolol-
dc.subjectChloramphenicol-
dc.subjectTrophic dilution-
dc.subjectRisk assessment-
dc.titleEnantiomer-specific bioaccumulation and distribution of chiral pharmaceuticals in a subtropical marine food web-
dc.typeArticle-
dc.identifier.emailLeung, KMY: kmyleung@hku.hk-
dc.identifier.authorityLeung, KMY=rp00733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhazmat.2020.122589-
dc.identifier.pmid32283383-
dc.identifier.scopuseid_2-s2.0-85082867919-
dc.identifier.hkuros311989-
dc.identifier.volume394-
dc.identifier.spagearticle no. 122589-
dc.identifier.epagearticle no. 122589-
dc.identifier.isiWOS:000532832200077-
dc.publisher.placeNetherlands-
dc.identifier.issnl0304-3894-

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