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Article: Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression

TitleRta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression
Authors
Issue Date2002
Citation
Blood, 2002, v. 100, n. 5, p. 1919-1921 How to Cite?
AbstractHuman herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellular genes has not been reported. We present evidence that the human IL-6 (hIL-6) gene is up-regulated by Rta. Rta potently activated (up to 164-fold) the hIL-6 promoter in a dose-dependent manner in a transient transfection reporter system. Rta also induced expression of the endogenous hIL-6 gene, as shown by enzyme-linked immunosorbent assays. Activation of the hIL-6 gene by HHV-8/KSHV supports the role of hIL-6 in the development of these malignancies. © 2002 by The American Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/285572
ISSN
2023 Impact Factor: 21.0
2023 SCImago Journal Rankings: 5.272
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDeng, Hongyu-
dc.contributor.authorChu, Julia T.-
dc.contributor.authorRettig, Matthew B.-
dc.contributor.authorMartinez-Maza, Otoniel-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:05Z-
dc.date.available2020-08-18T04:56:05Z-
dc.date.issued2002-
dc.identifier.citationBlood, 2002, v. 100, n. 5, p. 1919-1921-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/285572-
dc.description.abstractHuman herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellular genes has not been reported. We present evidence that the human IL-6 (hIL-6) gene is up-regulated by Rta. Rta potently activated (up to 164-fold) the hIL-6 promoter in a dose-dependent manner in a transient transfection reporter system. Rta also induced expression of the endogenous hIL-6 gene, as shown by enzyme-linked immunosorbent assays. Activation of the hIL-6 gene by HHV-8/KSHV supports the role of hIL-6 in the development of these malignancies. © 2002 by The American Society of Hematology.-
dc.languageeng-
dc.relation.ispartofBlood-
dc.titleRta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1182/blood-2002-01-0015-
dc.identifier.pmid12176919-
dc.identifier.scopuseid_2-s2.0-0036720832-
dc.identifier.volume100-
dc.identifier.issue5-
dc.identifier.spage1919-
dc.identifier.epage1921-
dc.identifier.isiWOS:000177667700058-
dc.identifier.issnl0006-4971-

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