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- Publisher Website: 10.1128/JVI.77.5.3301-3306.2003
- Scopus: eid_2-s2.0-0037372313
- PMID: 12584354
- WOS: WOS:000180999700052
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Article: Inhibition of gammaherpesvirus replication by RNA interference
Title | Inhibition of gammaherpesvirus replication by RNA interference |
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Authors | |
Issue Date | 2003 |
Citation | Journal of Virology, 2003, v. 77, n. 5, p. 3301-3306 How to Cite? |
Abstract | RNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production. |
Persistent Identifier | http://hdl.handle.net/10722/285574 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jia, Qingmei | - |
dc.contributor.author | Sun, Ren | - |
dc.date.accessioned | 2020-08-18T04:56:06Z | - |
dc.date.available | 2020-08-18T04:56:06Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Virology, 2003, v. 77, n. 5, p. 3301-3306 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285574 | - |
dc.description.abstract | RNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Virology | - |
dc.title | Inhibition of gammaherpesvirus replication by RNA interference | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JVI.77.5.3301-3306.2003 | - |
dc.identifier.pmid | 12584354 | - |
dc.identifier.pmcid | PMC149755 | - |
dc.identifier.scopus | eid_2-s2.0-0037372313 | - |
dc.identifier.volume | 77 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 3301 | - |
dc.identifier.epage | 3306 | - |
dc.identifier.isi | WOS:000180999700052 | - |
dc.identifier.issnl | 0022-538X | - |