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- Publisher Website: 10.1016/j.jmb.2005.08.011
- Scopus: eid_2-s2.0-24944513096
- PMID: 16140327
- WOS: WOS:000232187100001
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Article: Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7 Å
Title | Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7 Å |
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Authors | |
Keywords | Herpesvirus Chemokine Chemotaxis HIV |
Issue Date | 2005 |
Citation | Journal of Molecular Biology, 2005, v. 352, n. 5, p. 1019-1028 How to Cite? |
Abstract | Viral macrophage inflammatory protein I (vMIP-I) is a chemokine encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous ligand is CCL1. The crystal structure of vMIP-I was determined at 1.7 Å for comparison with other chemokines, especially those that bind CCR8, such as vMIP-II from KSHV, a CCR8 antagonist and the closest homolog (40% identical). vMIP-I has a typical chemokine fold consisting of an extended N-terminal loop, followed by a three-stranded antiparallel β-sheet and a C-terminal α-helix. The four molecules in the asymmetric unit comprise two MIP-1β-like dimers. Electrostatic surface representations of CCR8-binding chemokines reveal only minor areas of correlating surface potential, which must be reconciled with promiscuity in receptor and glycosaminoglycan (GAG) binding. In addition, the biological relevance of chemokine oligomerization is examined by comparing the oligomeric states of all chemokine structures deposited to date in the RCSB PDB. © 2005 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/285595 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 2.212 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Luz, John G. | - |
dc.contributor.author | Yu, Minmin | - |
dc.contributor.author | Su, Ying | - |
dc.contributor.author | Wu, Zining | - |
dc.contributor.author | Zhou, Zhou | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Wilson, Ian A. | - |
dc.date.accessioned | 2020-08-18T04:56:09Z | - |
dc.date.available | 2020-08-18T04:56:09Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Molecular Biology, 2005, v. 352, n. 5, p. 1019-1028 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285595 | - |
dc.description.abstract | Viral macrophage inflammatory protein I (vMIP-I) is a chemokine encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous ligand is CCL1. The crystal structure of vMIP-I was determined at 1.7 Å for comparison with other chemokines, especially those that bind CCR8, such as vMIP-II from KSHV, a CCR8 antagonist and the closest homolog (40% identical). vMIP-I has a typical chemokine fold consisting of an extended N-terminal loop, followed by a three-stranded antiparallel β-sheet and a C-terminal α-helix. The four molecules in the asymmetric unit comprise two MIP-1β-like dimers. Electrostatic surface representations of CCR8-binding chemokines reveal only minor areas of correlating surface potential, which must be reconciled with promiscuity in receptor and glycosaminoglycan (GAG) binding. In addition, the biological relevance of chemokine oligomerization is examined by comparing the oligomeric states of all chemokine structures deposited to date in the RCSB PDB. © 2005 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Molecular Biology | - |
dc.subject | Herpesvirus | - |
dc.subject | Chemokine | - |
dc.subject | Chemotaxis | - |
dc.subject | HIV | - |
dc.title | Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7 Å | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jmb.2005.08.011 | - |
dc.identifier.pmid | 16140327 | - |
dc.identifier.scopus | eid_2-s2.0-24944513096 | - |
dc.identifier.volume | 352 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1019 | - |
dc.identifier.epage | 1028 | - |
dc.identifier.isi | WOS:000232187100001 | - |
dc.identifier.issnl | 0022-2836 | - |