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- Publisher Website: 10.1128/JVI.00001-07
- Scopus: eid_2-s2.0-35348819393
- PMID: 17634244
- WOS: WOS:000249315200024
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Article: The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication
Title | The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication |
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Authors | |
Issue Date | 2007 |
Citation | Journal of Virology, 2007, v. 81, n. 18, p. 9870-9877 How to Cite? |
Abstract | Our functional mapping study of murine gammaherpesvirus 68 (MHV-68, or γHV-68) revealed that a mutant harboring a transposon at the ORF49 locus (ORF49null) evidenced a highly attenuated in vitro growth. ORF49 resides adjacent to and in an opposite direction from RTA, the primary switch of the gammaherpesvirus life cycle. A FLAG-tagged ORF49 protein was able to transcomplement ORF49null, and a revertant of ORF49null restored its attenuated growth to a level comparable to that of the wild type. The FLAG-tagged ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced virus replication from the ORF50null virus in the presence of RTA. Furthermore, ORF49 enhanced wild-type virus replication by increasing the RTA transcript levels. Our data indicate that ORF49 may perform an important function in MHV-68 replication in cooperation with RTA. Copyright © 2007, American Society for Microbiology. All Rights Reserved. |
Persistent Identifier | http://hdl.handle.net/10722/285608 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, Sangmi | - |
dc.contributor.author | Cho, Hye Jeong | - |
dc.contributor.author | Park, Jung Jin | - |
dc.contributor.author | Kim, Yong Sun | - |
dc.contributor.author | Hwang, Seungmin | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Moon, Jung Song | - |
dc.date.accessioned | 2020-08-18T04:56:11Z | - |
dc.date.available | 2020-08-18T04:56:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Virology, 2007, v. 81, n. 18, p. 9870-9877 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285608 | - |
dc.description.abstract | Our functional mapping study of murine gammaherpesvirus 68 (MHV-68, or γHV-68) revealed that a mutant harboring a transposon at the ORF49 locus (ORF49null) evidenced a highly attenuated in vitro growth. ORF49 resides adjacent to and in an opposite direction from RTA, the primary switch of the gammaherpesvirus life cycle. A FLAG-tagged ORF49 protein was able to transcomplement ORF49null, and a revertant of ORF49null restored its attenuated growth to a level comparable to that of the wild type. The FLAG-tagged ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced virus replication from the ORF50null virus in the presence of RTA. Furthermore, ORF49 enhanced wild-type virus replication by increasing the RTA transcript levels. Our data indicate that ORF49 may perform an important function in MHV-68 replication in cooperation with RTA. Copyright © 2007, American Society for Microbiology. All Rights Reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Virology | - |
dc.title | The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JVI.00001-07 | - |
dc.identifier.pmid | 17634244 | - |
dc.identifier.pmcid | PMC2045426 | - |
dc.identifier.scopus | eid_2-s2.0-35348819393 | - |
dc.identifier.volume | 81 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | 9870 | - |
dc.identifier.epage | 9877 | - |
dc.identifier.isi | WOS:000249315200024 | - |
dc.identifier.issnl | 0022-538X | - |