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Article: A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

TitleA repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon
Authors
Issue Date2008
Citation
Journal of Virology, 2008, v. 82, n. 5, p. 2208-2217 How to Cite?
AbstractInnate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/285615
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSanchez, David Jesse-
dc.contributor.authorMiranda, Daniel-
dc.contributor.authorArumugaswami, Vaithilingaraja-
dc.contributor.authorHwang, Seungmin-
dc.contributor.authorSinger, Adam E.-
dc.contributor.authorSenaati, Ashkon-
dc.contributor.authorShahangian, Arash-
dc.contributor.authorSong, Moon Jung-
dc.contributor.authorSun, Ren-
dc.contributor.authorCheng, Genhong-
dc.date.accessioned2020-08-18T04:56:12Z-
dc.date.available2020-08-18T04:56:12Z-
dc.date.issued2008-
dc.identifier.citationJournal of Virology, 2008, v. 82, n. 5, p. 2208-2217-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/285615-
dc.description.abstractInnate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. Copyright © 2008, American Society for Microbiology. All Rights Reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Virology-
dc.titleA repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.01718-07-
dc.identifier.pmid18077715-
dc.identifier.pmcidPMC2258961-
dc.identifier.scopuseid_2-s2.0-39749095030-
dc.identifier.volume82-
dc.identifier.issue5-
dc.identifier.spage2208-
dc.identifier.epage2217-
dc.identifier.isiWOS:000253481000016-
dc.identifier.f10001098575-
dc.identifier.issnl0022-538X-

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