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Article: Regulation of kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways

TitleRegulation of kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways
Authors
KeywordsSignal transduction
Herpesvirus reactivation
Dopamine
KSHV
Issue Date2008
Citation
Journal of Acquired Immune Deficiency Syndromes, 2008, v. 48, n. 5, p. 531-540 How to Cite?
AbstractBACKGROUND:: Kaposi's sarcoma-associated herpesvirus (KSHV) possesses two distinct life cycles, lytic replication and latency. An immediate early viral protein, Replication and transcription activator (RTA), is responsible for the virus switch from latency to active replication. METHODS:: To identify cellular pathways that reactivate KSHV replication, an RTA-responsive viral early promoter, PAN, coupled with an enhanced green fluorescent protein (EGFP) reporter was delivered into a KSHV latently infected B cell line. Five different chemical libraries with defined cellular targets were screened for their ability to induce the PAN promoter as an indication of lytic replication. RESULTS:: We identified seven chemicals that disrupted latency in KSHV latently infected B cells, five being N-acyl-dopamine derivatives. We showed that these chemicals reactivate KSHV through interacting with dopamine receptors, and that KSHV utilizes dopamine receptors and the associated PKA and MAP kinase pathways to detect and transmit stress signals for reactivation. CONCLUSION:: Our study identified two cellular signaling pathways that mediate KSHV reactivation and provided a chemical genetics approach to identify new endogenous activators with therapeutic potential against herpesvirus associated malignancies. © 2008 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/285632
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 1.225
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Shaoying-
dc.contributor.authorDeng, Hongyu-
dc.contributor.authorYu, Fuqu-
dc.contributor.authorMelega, William P.-
dc.contributor.authorDamoiseaux, Robert-
dc.contributor.authorBradley, Kenneth A.-
dc.contributor.authorSun, Ren-
dc.date.accessioned2020-08-18T04:56:15Z-
dc.date.available2020-08-18T04:56:15Z-
dc.date.issued2008-
dc.identifier.citationJournal of Acquired Immune Deficiency Syndromes, 2008, v. 48, n. 5, p. 531-540-
dc.identifier.issn1525-4135-
dc.identifier.urihttp://hdl.handle.net/10722/285632-
dc.description.abstractBACKGROUND:: Kaposi's sarcoma-associated herpesvirus (KSHV) possesses two distinct life cycles, lytic replication and latency. An immediate early viral protein, Replication and transcription activator (RTA), is responsible for the virus switch from latency to active replication. METHODS:: To identify cellular pathways that reactivate KSHV replication, an RTA-responsive viral early promoter, PAN, coupled with an enhanced green fluorescent protein (EGFP) reporter was delivered into a KSHV latently infected B cell line. Five different chemical libraries with defined cellular targets were screened for their ability to induce the PAN promoter as an indication of lytic replication. RESULTS:: We identified seven chemicals that disrupted latency in KSHV latently infected B cells, five being N-acyl-dopamine derivatives. We showed that these chemicals reactivate KSHV through interacting with dopamine receptors, and that KSHV utilizes dopamine receptors and the associated PKA and MAP kinase pathways to detect and transmit stress signals for reactivation. CONCLUSION:: Our study identified two cellular signaling pathways that mediate KSHV reactivation and provided a chemical genetics approach to identify new endogenous activators with therapeutic potential against herpesvirus associated malignancies. © 2008 by Lippincott Williams & Wilkins.-
dc.languageeng-
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromes-
dc.subjectSignal transduction-
dc.subjectHerpesvirus reactivation-
dc.subjectDopamine-
dc.subjectKSHV-
dc.titleRegulation of kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/QAI.0b013e31817fbdcf-
dc.identifier.pmid18645521-
dc.identifier.scopuseid_2-s2.0-50949118028-
dc.identifier.volume48-
dc.identifier.issue5-
dc.identifier.spage531-
dc.identifier.epage540-
dc.identifier.isiWOS:000258082200003-
dc.identifier.issnl1525-4135-

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