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- Publisher Website: 10.4049/jimmunol.1102621
- Scopus: eid_2-s2.0-84856587352
- PMID: 22198955
- WOS: WOS:000299690200018
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Article: Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine γ-herpesvirus-68
Title | Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine γ-herpesvirus-68 |
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Authors | |
Issue Date | 2012 |
Citation | Journal of Immunology, 2012, v. 188, n. 3, p. 1049-1056 How to Cite? |
Abstract | The human γ-herpesviruses EBV and Kaposi's sarcoma-associated herpesvirus establish lifelong latent infections, can reactivate in immunocompromised individuals, and are associated with the development of malignancies. Murine γ-herpesvirus-68 (γHV68), a rodent pathogen related to EBV and Kaposi's sarcoma-associated herpesvirus, provides an important model to dissect mechanisms of immune control and investigate vaccine strategies. Infection of mice with γHV68 elicits robust antiviral immunity, and long-term protection from γHV68 reactivation requires both cellular and humoral immune responses. Vaccination of mice with AC-replication and transcription activator (RTA), a highly lytic latency-null recombinant γHV68, results in complete protection from wild-type γHV68 infection that lasts for at least 10 mo. In this report, we examine the immune correlates of AC-RTA-mediated protection and show that sterilizing immunity requires both T cells and Ab. Importantly, Ab was also critical for mitigating viral infection in the brain, and in the absence of Ab-mediated control, amplification of the AC-RTA virus in the brain resulted in fatality. Our results highlight important considerations in the development of vaccination strategies based on live-attenuated viruses. Copyright © 2012 by The American Association of Immunologists, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/285690 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Freeman, Michael L. | - |
dc.contributor.author | Burkum, Claire E. | - |
dc.contributor.author | Woodland, David L. | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Wu, Ting Ting | - |
dc.contributor.author | Blackman, Marcia A. | - |
dc.date.accessioned | 2020-08-18T04:56:23Z | - |
dc.date.available | 2020-08-18T04:56:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Immunology, 2012, v. 188, n. 3, p. 1049-1056 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285690 | - |
dc.description.abstract | The human γ-herpesviruses EBV and Kaposi's sarcoma-associated herpesvirus establish lifelong latent infections, can reactivate in immunocompromised individuals, and are associated with the development of malignancies. Murine γ-herpesvirus-68 (γHV68), a rodent pathogen related to EBV and Kaposi's sarcoma-associated herpesvirus, provides an important model to dissect mechanisms of immune control and investigate vaccine strategies. Infection of mice with γHV68 elicits robust antiviral immunity, and long-term protection from γHV68 reactivation requires both cellular and humoral immune responses. Vaccination of mice with AC-replication and transcription activator (RTA), a highly lytic latency-null recombinant γHV68, results in complete protection from wild-type γHV68 infection that lasts for at least 10 mo. In this report, we examine the immune correlates of AC-RTA-mediated protection and show that sterilizing immunity requires both T cells and Ab. Importantly, Ab was also critical for mitigating viral infection in the brain, and in the absence of Ab-mediated control, amplification of the AC-RTA virus in the brain resulted in fatality. Our results highlight important considerations in the development of vaccination strategies based on live-attenuated viruses. Copyright © 2012 by The American Association of Immunologists, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Immunology | - |
dc.title | Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine γ-herpesvirus-68 | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.4049/jimmunol.1102621 | - |
dc.identifier.pmid | 22198955 | - |
dc.identifier.pmcid | PMC3262927 | - |
dc.identifier.scopus | eid_2-s2.0-84856587352 | - |
dc.identifier.volume | 188 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1049 | - |
dc.identifier.epage | 1056 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.isi | WOS:000299690200018 | - |
dc.identifier.issnl | 0022-1767 | - |