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Article: A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export

TitleA Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export
Authors
KeywordsNup98
mRNA nuclear export
late gene
3′ UTR
KSHV
Rae1
ORF10
herpesvirus
Issue Date2016
Citation
Cell Host and Microbe, 2016, v. 20, n. 5, p. 642-653 How to Cite?
Abstract© 2016 Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome-wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3′ UTRs of ORF10-targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions. These results suggest that a nuclear DNA virus can selectively interfere with RNA export to restrict host gene expression for optimal replication.
Persistent Identifierhttp://hdl.handle.net/10722/285780
ISSN
2023 Impact Factor: 20.6
2023 SCImago Journal Rankings: 7.760
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGong, Danyang-
dc.contributor.authorKim, Yong Hoon-
dc.contributor.authorXiao, Yuchen-
dc.contributor.authorDu, Yushen-
dc.contributor.authorXie, Yafang-
dc.contributor.authorLee, Kevin K.-
dc.contributor.authorFeng, Jun-
dc.contributor.authorFarhat, Nisar-
dc.contributor.authorZhao, Dawei-
dc.contributor.authorShu, Sara-
dc.contributor.authorDai, Xinghong-
dc.contributor.authorChanda, Sumit K.-
dc.contributor.authorRana, Tariq M.-
dc.contributor.authorKrogan, Nevan J.-
dc.contributor.authorSun, Ren-
dc.contributor.authorWu, Ting Ting-
dc.date.accessioned2020-08-18T04:56:37Z-
dc.date.available2020-08-18T04:56:37Z-
dc.date.issued2016-
dc.identifier.citationCell Host and Microbe, 2016, v. 20, n. 5, p. 642-653-
dc.identifier.issn1931-3128-
dc.identifier.urihttp://hdl.handle.net/10722/285780-
dc.description.abstract© 2016 Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome-wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3′ UTRs of ORF10-targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions. These results suggest that a nuclear DNA virus can selectively interfere with RNA export to restrict host gene expression for optimal replication.-
dc.languageeng-
dc.relation.ispartofCell Host and Microbe-
dc.subjectNup98-
dc.subjectmRNA nuclear export-
dc.subjectlate gene-
dc.subject3′ UTR-
dc.subjectKSHV-
dc.subjectRae1-
dc.subjectORF10-
dc.subjectherpesvirus-
dc.titleA Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.chom.2016.10.004-
dc.identifier.pmid27832591-
dc.identifier.pmcidPMC5130111-
dc.identifier.scopuseid_2-s2.0-84994726281-
dc.identifier.volume20-
dc.identifier.issue5-
dc.identifier.spage642-
dc.identifier.epage653-
dc.identifier.eissn1934-6069-
dc.identifier.isiWOS:000389472000013-
dc.identifier.issnl1931-3128-

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