File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer’s Disease in 3×Tg-AD Model Mice

TitleNeurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer’s Disease in 3×Tg-AD Model Mice
Authors
KeywordsAlzheimer’s disease
amyloid-β
behavior
locus coeruleus
neurodegeneration
Issue Date2020
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal of Alzheimer's Disease, 2020, v. 76 n. 4, p. 1443-1459 How to Cite?
AbstractBackground: The mesencephalic trigeminal nucleus (Vmes) is not only anatomically adjacent to the locus coeruleus (LC) but is also tightly associated with the function of the LC. The LC can be the first area in which Alzheimer’s disease (AD) develops, although it is unclear how LC neuronal loss occurs. Objective: We investigated whether neuronal death in the Vmes can be spread to adjacent LC in female triple transgenic (3×Tg)-AD mice, how amyloid-β (Aβ) is involved in LC neuronal loss, and how this neurodegeneration affects cognitive function. Methods: The molars of 3×Tg-AD mice were extracted, and the mice were reared for one week to 4 months. Immunohistochemical analysis, and spatial learning/memory assessment using the Barnes maze were carried out. Results: In 4-month-old 3×Tg-AD mice, aggregated cytotoxic Aβ42 was found in granules in Vmes neurons. Neuronal death in the Vmes occurred after tooth extraction, resulting in the release of cytotoxic Aβ42 and an increase in CD86 immunoreactive microglia. Released Aβ42 damaged the LC, in turn inducing a significant reduction in hippocampal neurons in the CA1 and CA3 regions receiving projections from the LC. Based on spatial learning/memory assessment, after the tooth extraction in the 4-month-old 3×Tg-AD mice, increased latency was observed in 5-month-old 3×Tg-AD mice 1 month after tooth extraction, which is similar increase of latency observed in control 8-month-old 3×Tg-AD mice. Measures of cognitive deficits suggested an earlier shift to dementia-like behavior after tooth extraction. Conclusion: These findings suggest that tooth extraction in the predementia stage can trigger the spread of neurodegeneration from the Vmes, LC, and hippocampus and accelerate the onset of dementia.
Persistent Identifierhttp://hdl.handle.net/10722/286677
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.172
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGoto, T-
dc.contributor.authorKuramoto, E-
dc.contributor.authorDhar, A-
dc.contributor.authorWang, RPH-
dc.contributor.authorSeki, H-
dc.contributor.authorIwai, H-
dc.contributor.authorYamanaka, A-
dc.contributor.authorMatsumoto, SE-
dc.contributor.authorHara, H-
dc.contributor.authorMichikawa, M-
dc.contributor.authorOhyagi, Y-
dc.contributor.authorLeung, WK-
dc.contributor.authorChang, RCC-
dc.date.accessioned2020-09-04T13:28:53Z-
dc.date.available2020-09-04T13:28:53Z-
dc.date.issued2020-
dc.identifier.citationJournal of Alzheimer's Disease, 2020, v. 76 n. 4, p. 1443-1459-
dc.identifier.issn1387-2877-
dc.identifier.urihttp://hdl.handle.net/10722/286677-
dc.description.abstractBackground: The mesencephalic trigeminal nucleus (Vmes) is not only anatomically adjacent to the locus coeruleus (LC) but is also tightly associated with the function of the LC. The LC can be the first area in which Alzheimer’s disease (AD) develops, although it is unclear how LC neuronal loss occurs. Objective: We investigated whether neuronal death in the Vmes can be spread to adjacent LC in female triple transgenic (3×Tg)-AD mice, how amyloid-β (Aβ) is involved in LC neuronal loss, and how this neurodegeneration affects cognitive function. Methods: The molars of 3×Tg-AD mice were extracted, and the mice were reared for one week to 4 months. Immunohistochemical analysis, and spatial learning/memory assessment using the Barnes maze were carried out. Results: In 4-month-old 3×Tg-AD mice, aggregated cytotoxic Aβ42 was found in granules in Vmes neurons. Neuronal death in the Vmes occurred after tooth extraction, resulting in the release of cytotoxic Aβ42 and an increase in CD86 immunoreactive microglia. Released Aβ42 damaged the LC, in turn inducing a significant reduction in hippocampal neurons in the CA1 and CA3 regions receiving projections from the LC. Based on spatial learning/memory assessment, after the tooth extraction in the 4-month-old 3×Tg-AD mice, increased latency was observed in 5-month-old 3×Tg-AD mice 1 month after tooth extraction, which is similar increase of latency observed in control 8-month-old 3×Tg-AD mice. Measures of cognitive deficits suggested an earlier shift to dementia-like behavior after tooth extraction. Conclusion: These findings suggest that tooth extraction in the predementia stage can trigger the spread of neurodegeneration from the Vmes, LC, and hippocampus and accelerate the onset of dementia.-
dc.languageeng-
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php-
dc.relation.ispartofJournal of Alzheimer's Disease-
dc.rightsThe final publication is available at IOS Press through https://doi.org/10.3233/JAD-200257-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAlzheimer’s disease-
dc.subjectamyloid-β-
dc.subjectbehavior-
dc.subjectlocus coeruleus-
dc.subjectneurodegeneration-
dc.titleNeurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer’s Disease in 3×Tg-AD Model Mice-
dc.typeArticle-
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityLeung, WK=rp00019-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3233/JAD-200257-
dc.identifier.pmid32651317-
dc.identifier.pmcidPMC7505011-
dc.identifier.scopuseid_2-s2.0-85089922335-
dc.identifier.hkuros314147-
dc.identifier.volume76-
dc.identifier.issue4-
dc.identifier.spage1443-
dc.identifier.epage1459-
dc.identifier.isiWOS:000562140000019-
dc.publisher.placeNetherlands-
dc.identifier.issnl1387-2877-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats