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Article: Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study
Title | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
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Authors | |
Keywords | Pregnancy Venous thromboembolism Chinese |
Issue Date | 2019 |
Publisher | Korean Society of Hematology. The Journal's web site is located at https://www.bloodresearch.or.kr/ |
Citation | Blood Research, 2019, v. 54 n. 3, p. 175-180 How to Cite? |
Abstract | Background:
Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism.
Methods:
In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed.
Results:
The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29?36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester.
Conclusion:
Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. |
Persistent Identifier | http://hdl.handle.net/10722/287158 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.609 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, D | - |
dc.contributor.author | Wong, E | - |
dc.contributor.author | Zuo, ML | - |
dc.contributor.author | Chan, PH | - |
dc.contributor.author | Yue, WS | - |
dc.contributor.author | Hu, HX | - |
dc.contributor.author | Chen, L | - |
dc.contributor.author | Yin, LX | - |
dc.contributor.author | Cui, XW | - |
dc.contributor.author | Wu, MX | - |
dc.contributor.author | Su, X | - |
dc.contributor.author | Siu, CW | - |
dc.contributor.author | Hai, JJ | - |
dc.date.accessioned | 2020-09-22T02:56:40Z | - |
dc.date.available | 2020-09-22T02:56:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Blood Research, 2019, v. 54 n. 3, p. 175-180 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | http://hdl.handle.net/10722/287158 | - |
dc.description.abstract | Background: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. Methods: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. Results: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29?36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. | - |
dc.language | eng | - |
dc.publisher | Korean Society of Hematology. The Journal's web site is located at https://www.bloodresearch.or.kr/ | - |
dc.relation.ispartof | Blood Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Pregnancy | - |
dc.subject | Venous thromboembolism | - |
dc.subject | Chinese | - |
dc.title | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study | - |
dc.type | Article | - |
dc.identifier.email | Chan, PH: phmchan@hku.hk | - |
dc.identifier.email | Siu, CW: cwdsiu@hkucc.hku.hk | - |
dc.identifier.email | Hai, JJ: haishjj@hku.hk | - |
dc.identifier.authority | Chan, PH=rp01864 | - |
dc.identifier.authority | Siu, CW=rp00534 | - |
dc.identifier.authority | Hai, JJ=rp02047 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.5045/br.2019.54.3.175 | - |
dc.identifier.pmid | 31730677 | - |
dc.identifier.pmcid | PMC6779932 | - |
dc.identifier.scopus | eid_2-s2.0-85074412938 | - |
dc.identifier.hkuros | 314480 | - |
dc.identifier.volume | 54 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 175 | - |
dc.identifier.epage | 180 | - |
dc.identifier.isi | WOS:000488260900006 | - |
dc.publisher.place | Republic of Korea | - |
dc.identifier.issnl | 2287-979X | - |