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- Publisher Website: 10.17796/1053-4625-43.5.6
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- PMID: 31560593
- WOS: WOS:000584293500006
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Article: Enhancing the remineralization potential of child formula dentifrices: an in vitro study
Title | Enhancing the remineralization potential of child formula dentifrices: an in vitro study |
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Authors | |
Keywords | Arginine Child Dentifrices Enamel Remineralization |
Issue Date | 2019 |
Publisher | Journal of Clinical Pediatric Dentistry. The Journal's web site is located at http://www.pediatricdentistry.com |
Citation | Journal of Clinical Pediatric Dentistry, 2019, v. 43 n. 5, p. 337-344 How to Cite? |
Abstract | Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit. The study objective was to examine the remineralizing potential of arginine in child formula dentifrice (600-ppm NaF).Study Design: Primary teeth enamel specimens (n = 10) with artificial caries-like lesion were randomly divided to 4 treatment groups: A: 2% Arg-(600-ppm) NaF; B: 600-ppm NaF; C: 1100-ppm NaF; and D: deionized water subjected to 7-day pH-cycling. The mineral density (MD) of the treated specimens was assessed using micro-CT. The pre-/post-treated artificial caries-like lesion were acid-etched for enamel fluoride uptake (EFU) evaluation, Ca and P element analysis using ICP-OES, and the inorganic phosphate (PO43−) determination using colorimetric assay. Results: The percentage remineralization of the 2% Arg-NaF and 1100-ppm NaF groups was significantly higher than the 600-ppm NaF group (p<0.001). However, no significant difference in remineralization was observed between the two groups (p>0.05). The EFU, Ca/P ratio, PO43− content of the 2% Arg-NaF group were significantly higher than the 600-ppm NaF group (p<0.01); while no significant difference was found between the 2% Arg-NaF and 1100-ppm NaF groups. Conclusion: Within the limitations of the present study, incorporation of 2% arginine in 600-ppm NaF child formula dentifrice enhanced the remineralization potential of artificial enamel caries, to a level comparable to 1100-ppm NaF adult formula dentifrice. |
Persistent Identifier | http://hdl.handle.net/10722/287261 |
ISSN | 2023 Impact Factor: 1.5 2023 SCImago Journal Rankings: 0.371 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bijle, MNA | - |
dc.contributor.author | Tung, LP | - |
dc.contributor.author | Wong, J | - |
dc.contributor.author | Ekambaram, M | - |
dc.contributor.author | Lo, ECM | - |
dc.contributor.author | Yiu, CKY | - |
dc.date.accessioned | 2020-09-22T02:58:18Z | - |
dc.date.available | 2020-09-22T02:58:18Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Clinical Pediatric Dentistry, 2019, v. 43 n. 5, p. 337-344 | - |
dc.identifier.issn | 1053-4628 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287261 | - |
dc.description.abstract | Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit. The study objective was to examine the remineralizing potential of arginine in child formula dentifrice (600-ppm NaF).Study Design: Primary teeth enamel specimens (n = 10) with artificial caries-like lesion were randomly divided to 4 treatment groups: A: 2% Arg-(600-ppm) NaF; B: 600-ppm NaF; C: 1100-ppm NaF; and D: deionized water subjected to 7-day pH-cycling. The mineral density (MD) of the treated specimens was assessed using micro-CT. The pre-/post-treated artificial caries-like lesion were acid-etched for enamel fluoride uptake (EFU) evaluation, Ca and P element analysis using ICP-OES, and the inorganic phosphate (PO43−) determination using colorimetric assay. Results: The percentage remineralization of the 2% Arg-NaF and 1100-ppm NaF groups was significantly higher than the 600-ppm NaF group (p<0.001). However, no significant difference in remineralization was observed between the two groups (p>0.05). The EFU, Ca/P ratio, PO43− content of the 2% Arg-NaF group were significantly higher than the 600-ppm NaF group (p<0.01); while no significant difference was found between the 2% Arg-NaF and 1100-ppm NaF groups. Conclusion: Within the limitations of the present study, incorporation of 2% arginine in 600-ppm NaF child formula dentifrice enhanced the remineralization potential of artificial enamel caries, to a level comparable to 1100-ppm NaF adult formula dentifrice. | - |
dc.language | eng | - |
dc.publisher | Journal of Clinical Pediatric Dentistry. The Journal's web site is located at http://www.pediatricdentistry.com | - |
dc.relation.ispartof | Journal of Clinical Pediatric Dentistry | - |
dc.subject | Arginine | - |
dc.subject | Child | - |
dc.subject | Dentifrices | - |
dc.subject | Enamel | - |
dc.subject | Remineralization | - |
dc.title | Enhancing the remineralization potential of child formula dentifrices: an in vitro study | - |
dc.type | Article | - |
dc.identifier.email | Ekambaram, M: drmani@hku.hk | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.email | Yiu, CKY: ckyyiu@hkucc.hku.hk | - |
dc.identifier.authority | Ekambaram, M=rp02026 | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.identifier.authority | Yiu, CKY=rp00018 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.17796/1053-4625-43.5.6 | - |
dc.identifier.pmid | 31560593 | - |
dc.identifier.scopus | eid_2-s2.0-85072713147 | - |
dc.identifier.hkuros | 314447 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 337 | - |
dc.identifier.epage | 344 | - |
dc.identifier.isi | WOS:000584293500006 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1053-4628 | - |