File Download
  Links for fulltext
     (May Require Subscription)

Article: Immune dysregulation in depression: Evidence from genome-wide association

TitleImmune dysregulation in depression: Evidence from genome-wide association
Authors
KeywordsDepression
GWAS
Genetics
Neuroscience
Psychiatry
Issue Date2020
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi
Citation
Brain, Behavior, and Immunity, 2020, v. 7, p. article no. 100108 How to Cite?
AbstractA strong body of evidence supports a role for immune dysregulation across many psychiatric disorders including depression, the leading cause of global disability. Recent progress in the search for genetic variants associated with depression provides the opportunity to strengthen our current understanding of etiological factors contributing to depression and generate novel hypotheses. Here, we provide an overview of the literature demonstrating a role for immune dysregulation in depression, followed by a detailed discussion of the immune-related genes identified by the most recent genome-wide meta-analysis of depression. These genes represent strong evidence-based targets for future basic and translational research which aims to understand the role of the immune system in depression pathology and identify novel points for therapeutic intervention.
Persistent Identifierhttp://hdl.handle.net/10722/287298
ISSN
2023 Impact Factor: 8.8
2023 SCImago Journal Rankings: 3.141

 

DC FieldValueLanguage
dc.contributor.authorTUBBS, JD-
dc.contributor.authorDING, J-
dc.contributor.authorBaum, L-
dc.contributor.authorSham, PC-
dc.date.accessioned2020-09-22T02:58:52Z-
dc.date.available2020-09-22T02:58:52Z-
dc.date.issued2020-
dc.identifier.citationBrain, Behavior, and Immunity, 2020, v. 7, p. article no. 100108-
dc.identifier.issn0889-1591-
dc.identifier.urihttp://hdl.handle.net/10722/287298-
dc.description.abstractA strong body of evidence supports a role for immune dysregulation across many psychiatric disorders including depression, the leading cause of global disability. Recent progress in the search for genetic variants associated with depression provides the opportunity to strengthen our current understanding of etiological factors contributing to depression and generate novel hypotheses. Here, we provide an overview of the literature demonstrating a role for immune dysregulation in depression, followed by a detailed discussion of the immune-related genes identified by the most recent genome-wide meta-analysis of depression. These genes represent strong evidence-based targets for future basic and translational research which aims to understand the role of the immune system in depression pathology and identify novel points for therapeutic intervention.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi-
dc.relation.ispartofBrain, Behavior, and Immunity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDepression-
dc.subjectGWAS-
dc.subjectGenetics-
dc.subjectNeuroscience-
dc.subjectPsychiatry-
dc.titleImmune dysregulation in depression: Evidence from genome-wide association-
dc.typeArticle-
dc.identifier.emailBaum, L: lwbaum@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.authoritySham, PC=rp00459-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bbih.2020.100108-
dc.identifier.hkuros314609-
dc.identifier.volume7-
dc.identifier.spagearticle no. 100108-
dc.identifier.epagearticle no. 100108-
dc.publisher.placeUnited States-
dc.identifier.issnl0889-1591-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats