File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s11325-020-02125-x
- Scopus: eid_2-s2.0-85086652406
- WOS: WOS:000543634400002
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats
| Title | The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats |
|---|---|
| Authors | |
| Keywords | Sleep apnea Chronic intermittent hypoxia 5-HT 5-HT 2A |
| Issue Date | 2020 |
| Publisher | Springer Verlag. The Journal's web site is located at http://www.springer.com/medicine/internal/journal/11325 |
| Citation | Sleep and Breathing, 2020, Epub 2020-06-19 How to Cite? |
| Abstract | Purpose:
To study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats.
Methods:
Adult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry.
Results:
The expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05).
Conclusion:
There were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH. |
| Persistent Identifier | http://hdl.handle.net/10722/287310 |
| ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.753 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Cao, R | - |
| dc.contributor.author | Zhang, MJ | - |
| dc.contributor.author | Zhou, YT | - |
| dc.contributor.author | Liu, YJ | - |
| dc.contributor.author | Wang, HH | - |
| dc.contributor.author | Zhang, QX | - |
| dc.contributor.author | Shi, YW | - |
| dc.contributor.author | Li, JC | - |
| dc.contributor.author | Wong, TS | - |
| dc.contributor.author | Yin, M | - |
| dc.date.accessioned | 2020-09-22T02:59:03Z | - |
| dc.date.available | 2020-09-22T02:59:03Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.citation | Sleep and Breathing, 2020, Epub 2020-06-19 | - |
| dc.identifier.issn | 1520-9512 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/287310 | - |
| dc.description.abstract | Purpose: To study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats. Methods: Adult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry. Results: The expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05). Conclusion: There were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH. | - |
| dc.language | eng | - |
| dc.publisher | Springer Verlag. The Journal's web site is located at http://www.springer.com/medicine/internal/journal/11325 | - |
| dc.relation.ispartof | Sleep and Breathing | - |
| dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
| dc.subject | Sleep apnea | - |
| dc.subject | Chronic intermittent hypoxia | - |
| dc.subject | 5-HT | - |
| dc.subject | 5-HT 2A | - |
| dc.title | The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats | - |
| dc.type | Article | - |
| dc.identifier.email | Wong, TS: wongtsa@hkucc.hku.hk | - |
| dc.identifier.authority | Wong, TS=rp00478 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1007/s11325-020-02125-x | - |
| dc.identifier.scopus | eid_2-s2.0-85086652406 | - |
| dc.identifier.hkuros | 314387 | - |
| dc.identifier.volume | Epub 2020-06-19 | - |
| dc.identifier.isi | WOS:000543634400002 | - |
| dc.publisher.place | Germany | - |
| dc.identifier.issnl | 1520-9512 | - |