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Article: Inflammasome activation and Th17 responses

TitleInflammasome activation and Th17 responses
Authors
KeywordsInflammasomes
IL-1β
IL-1R
T-helper cells
Th17
Issue Date2019
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
Citation
Molecular Immunology, 2019, v. 107, p. 142-164 How to Cite?
AbstractImmune sensing of exogenous molecules from microbes (e.g., pathogen-associated molecular patterns) and nonmicrobial molecules (e.g., asbestos, alum, and silica), as well as endogenous damage-associated molecular patterns (e.g., ATP, uric acid crystals, and amyloid A) activates innate immunity by inducing immune-related genes, including proinflammatory cytokines, which further facilitate the development of adaptive immunity. The roles of transcriptional responses downstream of immune sensing have been widely characterized in informing adaptive immunity; however, few studies focus on the effect of post-translational responses on the modulation of adaptive immune responses. Inflammasomes activated by the previously described endo- and exogenous stimuli autocatalytically induce intracellular pro-caspase-1, which cleaves the inactive precursors of interleukin-1β (IL-1β) and IL-18 into bioactive proinflammatory cytokines. IL-1β and IL-18 not only contribute to the host defense against infections by activating phagocytes, such as monocytes, macrophages, dendritic cells, and neutrophils, but also induce T-helper 17 (Th17)- and Th1-mediated adaptive immune responses. In synergy with IL-6 and IL-23, IL-1β activates IL-1 receptor (IL-1R) signaling to drive the differentiation of IL-17-producing Th17 cells, which not only play critical roles in host protective immunity to infections of bacteria, fungi, and certain viruses but also participate in the pathology of inflammatory disorders and tumorigenesis. Consequently, targeting inflammasomes and IL-1/IL-1R signaling may effectively improve the treatment of Th17-associated disorders, such as autoinflammatory diseases and cancers, thereby providing novel insights into drug development.
Persistent Identifierhttp://hdl.handle.net/10722/287591
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.892
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDENG, J-
dc.contributor.authorYu, XQ-
dc.contributor.authorWang, PH-
dc.date.accessioned2020-10-05T12:00:19Z-
dc.date.available2020-10-05T12:00:19Z-
dc.date.issued2019-
dc.identifier.citationMolecular Immunology, 2019, v. 107, p. 142-164-
dc.identifier.issn0161-5890-
dc.identifier.urihttp://hdl.handle.net/10722/287591-
dc.description.abstractImmune sensing of exogenous molecules from microbes (e.g., pathogen-associated molecular patterns) and nonmicrobial molecules (e.g., asbestos, alum, and silica), as well as endogenous damage-associated molecular patterns (e.g., ATP, uric acid crystals, and amyloid A) activates innate immunity by inducing immune-related genes, including proinflammatory cytokines, which further facilitate the development of adaptive immunity. The roles of transcriptional responses downstream of immune sensing have been widely characterized in informing adaptive immunity; however, few studies focus on the effect of post-translational responses on the modulation of adaptive immune responses. Inflammasomes activated by the previously described endo- and exogenous stimuli autocatalytically induce intracellular pro-caspase-1, which cleaves the inactive precursors of interleukin-1β (IL-1β) and IL-18 into bioactive proinflammatory cytokines. IL-1β and IL-18 not only contribute to the host defense against infections by activating phagocytes, such as monocytes, macrophages, dendritic cells, and neutrophils, but also induce T-helper 17 (Th17)- and Th1-mediated adaptive immune responses. In synergy with IL-6 and IL-23, IL-1β activates IL-1 receptor (IL-1R) signaling to drive the differentiation of IL-17-producing Th17 cells, which not only play critical roles in host protective immunity to infections of bacteria, fungi, and certain viruses but also participate in the pathology of inflammatory disorders and tumorigenesis. Consequently, targeting inflammasomes and IL-1/IL-1R signaling may effectively improve the treatment of Th17-associated disorders, such as autoinflammatory diseases and cancers, thereby providing novel insights into drug development.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm-
dc.relation.ispartofMolecular Immunology-
dc.subjectInflammasomes-
dc.subjectIL-1β-
dc.subjectIL-1R-
dc.subjectT-helper cells-
dc.subjectTh17-
dc.titleInflammasome activation and Th17 responses-
dc.typeArticle-
dc.identifier.emailWang, PH: pei-hui.wang@connect.hku.hk-
dc.identifier.doi10.1016/j.molimm.2018.12.024-
dc.identifier.pmid30739833-
dc.identifier.scopuseid_2-s2.0-85061194235-
dc.identifier.hkuros315708-
dc.identifier.volume107-
dc.identifier.spage142-
dc.identifier.epage164-
dc.identifier.isiWOS:000459951400018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0161-5890-

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