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Conference Paper: Comparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management
Title | Comparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management |
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Authors | |
Keywords | sepsis radiation therapy craniopharyngioma disease progression fatal outcome |
Issue Date | 2018 |
Publisher | Oxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org |
Citation | The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018), Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i42, article no. CRAN-26 How to Cite? |
Abstract | BACKGROUND: The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches.
METHOD: This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis.
RESULT: From Jan 1994 to Dec 2016 (13-yrs), 21 children (<18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children<15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted.
CONCLUSION: If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome. |
Persistent Identifier | http://hdl.handle.net/10722/287601 |
ISSN | 2023 Impact Factor: 16.4 2023 SCImago Journal Rankings: 6.348 |
DC Field | Value | Language |
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dc.contributor.author | Chan, GCF | - |
dc.contributor.author | Ku, DTL | - |
dc.contributor.author | Luk, CW | - |
dc.contributor.author | Ling, ASC | - |
dc.contributor.author | Shing, MMK | - |
dc.contributor.author | Liu, APY | - |
dc.date.accessioned | 2020-10-05T12:00:28Z | - |
dc.date.available | 2020-10-05T12:00:28Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018), Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i42, article no. CRAN-26 | - |
dc.identifier.issn | 1522-8517 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287601 | - |
dc.description.abstract | BACKGROUND: The management approach for craniopharyngioma has not reach a consensus between neurosurgeons and radiation oncologists for the past decades. We reviewed our experience and assessed the outcome of these 2 approaches. METHOD: This is a retrospective review and children with oncological conditions were admitted to 5 public hospitals. Their data were collected prospectively by 2 full time data managers. Patients’ progress was updated annually and the data were crossed checked by the principle investigators. Survival data was analyzed by the Kaplan-Meier Analysis. RESULT: From Jan 1994 to Dec 2016 (13-yrs), 21 children (<18yrs) with craniopharyngioma was identified. The estimated incidence was 1.47/million children<15yrs/yr. M:F=10:9 and median age was 9.7yrs (range 2mons to 16.5yrs). 12/21 (57%) children were treated with surgery alone as primary approach. Even statistically insignificant, the 6yrs relapse-free-survival was 80% vs 50.3% between surgery+radiation therapy (RT) vs surgery alone. 8/13(61.5%) children in one hospital (HospA) were treated with surgery+RT as primary approach if there was residual lesion post-operatively, but other hospitals (Others) mainly adopted surgery alone as primary approach. The relapsed rate was only 1/13 (7.7%) from HospA. However, 6/8 (75%) patients in Others relapsed and 3 patients eventually died (2 disease progression; 1 sepsis). The overall incidence of hypopituitarism was lower in the HospA (72% vs 87.5%). No other radiation induced complication was noted. CONCLUSION: If with residue, surgery alone approach for craniopharyngioma is associated with a high risk of relapse. Despite being a benign tumor, patients with multiple relapses can have fatal outcome. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org | - |
dc.relation.ispartof | Neuro-Oncology | - |
dc.relation.ispartof | The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) | - |
dc.subject | sepsis | - |
dc.subject | radiation therapy | - |
dc.subject | craniopharyngioma | - |
dc.subject | disease progression | - |
dc.subject | fatal outcome | - |
dc.title | Comparing Surgery Alone or Surgery plus Radiation Therapy in Craniopharyngioma Management | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | - |
dc.identifier.email | Liu, APY: apyliu@hku.hk | - |
dc.identifier.authority | Chan, GCF=rp00431 | - |
dc.identifier.authority | Liu, APY=rp01357 | - |
dc.description.nature | abstract | - |
dc.identifier.doi | 10.1093/neuonc/noy059.062 | - |
dc.identifier.hkuros | 315020 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | Suppl. 2 | - |
dc.identifier.spage | i42 | - |
dc.identifier.epage | i42 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1522-8517 | - |