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Article: Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

TitleIntroducing aldehyde functionality to proteins using ligand-directed affinity labeling
Authors
KeywordsLabeling procedures
Native proteins
One pot
Protein modifications
Target binding
Issue Date2020
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2020, v. 56 n. 45, p. 6134-6137 How to Cite?
AbstractAldehyde is a versatile chemical handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, we report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure.
Persistent Identifierhttp://hdl.handle.net/10722/287613
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.133
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Y-
dc.contributor.authorXiong, F-
dc.contributor.authorPeng, J-
dc.contributor.authorFung, YME-
dc.contributor.authorHuang, Y-
dc.contributor.authorLi, X-
dc.date.accessioned2020-10-05T12:00:39Z-
dc.date.available2020-10-05T12:00:39Z-
dc.date.issued2020-
dc.identifier.citationChemical Communications, 2020, v. 56 n. 45, p. 6134-6137-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/287613-
dc.description.abstractAldehyde is a versatile chemical handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, we report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp-
dc.relation.ispartofChemical Communications-
dc.subjectLabeling procedures-
dc.subjectNative proteins-
dc.subjectOne pot-
dc.subjectProtein modifications-
dc.subjectTarget binding-
dc.titleIntroducing aldehyde functionality to proteins using ligand-directed affinity labeling-
dc.typeArticle-
dc.identifier.emailPeng, J: pengjz@HKUCC-COM.hku.hk-
dc.identifier.emailFung, YME: eva.fungym@hku.hk-
dc.identifier.emailHuang, Y: huangyr0@hku.hk-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityFung, YME=rp01986-
dc.identifier.authorityLi, X=rp02080-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/D0CC01982H-
dc.identifier.pmid32364188-
dc.identifier.scopuseid_2-s2.0-85085987179-
dc.identifier.hkuros315340-
dc.identifier.volume56-
dc.identifier.issue45-
dc.identifier.spage6134-
dc.identifier.epage6137-
dc.identifier.isiWOS:000542111600024-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1359-7345-

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