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Article: Neuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life

TitleNeuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life
Authors
KeywordsLow-grade glioma
Brain tumor
Infancy
Cancer
Neuropsychological
Issue Date2019
PublisherSpringer New York LLC. The Journal's web site is located at https://www.springer.com/medicine/oncology/journal/11060
Citation
Journal of Neuro-Oncology, 2019, v. 141, p. 413-420 How to Cite?
AbstractPurpose: Low-grade gliomas (LGG) are a heterogeneous group of brain tumors, which are often assumed to have a benign course. Yet, children diagnosed and treated for LGG in infancy are at increased risk for neurodevelopmental disruption. We sought to investigate neuropsychological outcomes of infants diagnosed with LGG. Methods: Between 1986 and 2013, 51 patients were diagnosed with LGG before 12 months of age and managed at St. Jude Children’s Research Hospital. Twenty-five of the 51 patients received a cognitive assessment (68% male; 6.8 ± 3.3 months at diagnosis; 10.5 ± 4.8 years at latest assessment). Approximately half the patients received radiation therapy (n = 12; aged 4.0 ± 3.0 years at radiation therapy), with a median of 2 chemotherapy regimens (range = 0–5) and 1 tumor directed surgery (range = 0–5). Results: The analyses revealed performance below age expectations on measures of IQ, memory, reading, mathematics, and fine motor functioning as well as parent-report of attention, executive, and adaptive functioning. Following correction for multiple comparisons, a greater number of chemotherapy regimens was associated with lower scores on measures of IQ and mathematics. More tumor directed surgeries and presence of visual field loss were associated with poorer dominant hand fine motor control. Radiation therapy exposure was not associated with decline in neuropsychological performance. Conclusions: Children diagnosed with LGG in infancy experience substantial neuropsychological deficits. Treatment factors, including number of chemotherapy regimens and tumor directed surgeries, may increase risk for neurodevelopmental disruption and need to be considered in treatment planning.
Persistent Identifierhttp://hdl.handle.net/10722/287695
ISSN
2020 Impact Factor: 4.13
2015 SCImago Journal Rankings: 1.274
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHeitzer, AM-
dc.contributor.authorAshford, JM-
dc.contributor.authorHastings, C-
dc.contributor.authorLiu, APY-
dc.contributor.authorWu, S-
dc.contributor.authorBass, JK-
dc.contributor.authorVestal, R-
dc.contributor.authorHoehn, M-
dc.contributor.authorChiang, J-
dc.contributor.authorGhazwani, Y-
dc.contributor.authorAcharya, S-
dc.contributor.authorBoop, F-
dc.contributor.authorGajjar, A-
dc.contributor.authorMerchant, TE-
dc.contributor.authorQaddoumi, I-
dc.contributor.authorConklin, HM-
dc.date.accessioned2020-10-05T12:01:54Z-
dc.date.available2020-10-05T12:01:54Z-
dc.date.issued2019-
dc.identifier.citationJournal of Neuro-Oncology, 2019, v. 141, p. 413-420-
dc.identifier.issn0167-594X-
dc.identifier.urihttp://hdl.handle.net/10722/287695-
dc.description.abstractPurpose: Low-grade gliomas (LGG) are a heterogeneous group of brain tumors, which are often assumed to have a benign course. Yet, children diagnosed and treated for LGG in infancy are at increased risk for neurodevelopmental disruption. We sought to investigate neuropsychological outcomes of infants diagnosed with LGG. Methods: Between 1986 and 2013, 51 patients were diagnosed with LGG before 12 months of age and managed at St. Jude Children’s Research Hospital. Twenty-five of the 51 patients received a cognitive assessment (68% male; 6.8 ± 3.3 months at diagnosis; 10.5 ± 4.8 years at latest assessment). Approximately half the patients received radiation therapy (n = 12; aged 4.0 ± 3.0 years at radiation therapy), with a median of 2 chemotherapy regimens (range = 0–5) and 1 tumor directed surgery (range = 0–5). Results: The analyses revealed performance below age expectations on measures of IQ, memory, reading, mathematics, and fine motor functioning as well as parent-report of attention, executive, and adaptive functioning. Following correction for multiple comparisons, a greater number of chemotherapy regimens was associated with lower scores on measures of IQ and mathematics. More tumor directed surgeries and presence of visual field loss were associated with poorer dominant hand fine motor control. Radiation therapy exposure was not associated with decline in neuropsychological performance. Conclusions: Children diagnosed with LGG in infancy experience substantial neuropsychological deficits. Treatment factors, including number of chemotherapy regimens and tumor directed surgeries, may increase risk for neurodevelopmental disruption and need to be considered in treatment planning.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at https://www.springer.com/medicine/oncology/journal/11060-
dc.relation.ispartofJournal of Neuro-Oncology-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectLow-grade glioma-
dc.subjectBrain tumor-
dc.subjectInfancy-
dc.subjectCancer-
dc.subjectNeuropsychological-
dc.titleNeuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life-
dc.typeArticle-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.authorityLiu, APY=rp01357-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s11060-018-03048-0-
dc.identifier.pmid30467811-
dc.identifier.pmcidPMC6344293-
dc.identifier.scopuseid_2-s2.0-85057164544-
dc.identifier.hkuros315670-
dc.identifier.volume141-
dc.identifier.spage413-
dc.identifier.epage420-
dc.identifier.isiWOS:000456445800017-
dc.publisher.placeUnited States-
dc.identifier.issnl0167-594X-

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